溃疡性结肠炎患者肠道菌群变化的临床研究  

Clinical Studies in Patients with Ulcerative Colitis Intestinal Flora Changes

作　　者：梁淑文[1] 王晓英[1] 屈昌民[1] 曹艳菊[1] 李连勇[1] 罗治文[1] 曾柏伦[1] 谢明水[2] 

机构地区：[1]中国人民解放军第306医院消化内科,北京100101 [2]湖北省随州市中心医院,441300

出　　处：《医学研究杂志》2015年第9期60-62,共3页Journal of Medical Research

基　　金：湖北省科技厅基金资助项目(2013CFB480)

摘　　要：目的探讨溃疡性结肠炎患者肠道菌群变化的临床意义。方法病例来源于2011年3月～2014年2月笔者医院确诊为溃疡性结肠炎（ulcerative colitis，UC）患者106例，依据研究分组时的病情状况分为活动期UC组66例，缓解期UC组40例，同时筛选出54例身体健康者作为健康组，比较3组大便细菌种群的结构与数量，检查3组样本血液中IL-10、IL-6、IL-4、TNF—α与内毒素水平等炎性指标。结果与缓解期UC组及健康组相比，活动期UC组病患乳酸杆菌、双歧杆菌、拟杆菌、真杆菌、消化球菌的菌群数量显著减少，大肠杆菌、肠球菌和小梭菌菌群数量显著增加，差异有统计学意义（P〈0．05）；缓解期UC组与健康组相比较，拟杆菌菌群数量降低明显（P〈0．05），其余菌群数量无明显改变，差异无统计学意义（P〉0．05）。与缓解期UC组及健康组相比较，活动期UC组IL-6、TNF—α与内毒素增高显著（P〈0．05），IL-10与IL-4降低明显（P〈0．05）。结论UC患者肠道正常菌群结构失衡，并导致机体肠道炎症，致使机体内部抑制炎症的因子分泌下降，促进炎症的因子分泌增多。Objective To investigate the changes of intestinal flora in patients with ulcerative colitis （UC） and the relationship be- tween the intestinal flora and disease. Methods Using the gradient dilution method, fecal samples from 53 patients with UC in our hospi- tal collected and 53 cases of healthy controls were analyzed and compared. Observe the number of intestinal flora （Enterobacter, Entero- coccus, Clostridium and Lactobacillus） in two groups. Results Compared with healthy people, the number of Enterobaeter, Enteroeoc- cus, Clostridium in UC patients were increased obviously, the number of Lactobacillus was significantly reduced. The difference has statis- tical significance. Conclusion In patients with UC, the reduced number of probiotics and the increased number of conditional pathogenic bacteria such as Enterobacter, Enterococcus lead to intestinal flora imbalance, immune disorders, which may lead to the onset of UC.

关 键 词：溃疡性结 肠炎肠道菌群 活动期 炎性因子 

分 类 号：R57[医药卫生—消化系统]