泛素耦联酶2C在乳腺癌中的作用及意义  

Roles of UBE2C in breast cancer and its clinical significance

作　　者：秦涛[1] 李曼[1] 

机构地区：[1]大连医科大学附属第二医院肿瘤科,116023

出　　处：《国际肿瘤学杂志》2015年第10期766-768,共3页Journal of International Oncology

基　　金：辽宁省自然科学基金（2014023025）

摘　　要：泛素耦联酶2C（UBE2C）参与细胞周期进展、有丝分裂调控以及靶向降解短寿命的蛋白质。UBE2C是癌症相关的泛素耦联酶，其在乳腺癌组织中表达高于癌旁正常组织。异常表达的UBE2C通过调控细胞周期进展、C-erbB-2、细胞凋亡因子及转移相关因子等，参与乳腺癌发生、发展及转移的过程，并且可对乳腺癌的诊断及预后提供参考价值。Ubiquitin-conjugating enzyme 2C （UBE2C） is involved in cell cycle progression, mitosis regulation and targeted degradation of short-lived proteins. UBE2C is the cancer-related ubiquitin-conjugating enzyme, which is significantly higher in breast cancer tissues compared to the adjacent normal tissue. The abnormal expression of UBE2C participates in the process of occurrence, development and metastasis of breast cancer by the regulation of cell cycle progression, C-erbB-2, cell apoptosis factors and metastasis related genes. It will provide reference for the diagnosis and prognosis of breast cancer.

关 键 词：细胞周期 乳腺肿瘤 泛素耦联酶2C 

分 类 号：R737.9[医药卫生—肿瘤]