淋巴瘤样肉芽肿临床病理分析  

Clinicopathological analysis of lymphomatoid granulomatosis

作　　者：郭培民[1] 袁淑红[2] 

机构地区：[1]山东省德州市人民医院病理科,德州253014 [2]山东省德州市人民医院妇产科,德州253014

出　　处：《临床医学》2015年第8期33-34,F0004,共3页Clinical Medicine

摘　　要：目的探讨淋巴瘤样肉芽肿的临床病理特征、免疫表型及鉴别诊断。方法对2例淋巴瘤样肉芽肿的临床病理学和组织病理学特征进行观察,结合免疫表型并复习文献。结果 2例淋巴瘤样肉芽肿显示以血管损害为主的淋巴组织病变,淋巴细胞呈多形性、不典型,显示为EB病毒感染的B细胞组成,并有大量的混合反应性T细胞。结论淋巴瘤样肉芽肿为一类罕见的低度恶性病变,显示组织学分级和临床侵袭性的变化谱系,与EB病毒阳性的大B细胞比例有关。淋巴瘤样肉芽肿可进展为EBV阳性的弥漫性大B细胞淋巴瘤。Objective To investigate the clinicopathological feature,immunophenotype and differential diagnosis of lymphomatoid granulomatosis. Methods The characteristics of clinicopathology and histopathology of 2 cases of lymphomatoid granulomatosis were observed,with immunophenotype and review of the literatures. Results Two cases of lymphomatoid granulomatosis showed the main lymphoproliferative lesions were vascular damaging,lymphocytes were polymorphic and atypical and were composed of the B cells of EB virus infection and a large number of mixed reactive T cells. Conclusion Lymphomatoid granulomatosis is a rare low-grade malignant lesions,showed changes of histological grading and clinical aggressiveness,associated with the ratio of positive B cells of EB virus. Lymphomatoid granulomatosis can progress to EBV positive diffuse large B cell lymphoma.

关 键 词：淋巴瘤样肉芽肿 EB病毒 免疫组化 

分 类 号：R733.1[医药卫生—肿瘤]