荔枝核有效部位群对α-葡萄糖苷酶的抑制作用  

Inhibition of Semen Litchi Effective Fractions on α-Glucosidase

作　　者：钟世顺 邓志军[2] 李常青[3] 沙聪威 郭洁文[2] 李丽明[2] 刘若轩[2] 李阿荣[2] 齐耀群 

机构地区：[1]广东省生物制品与药物研究所,广东广州510440 [2]广州市中医医院,广东广州510130 [3]广州中医药大学热带医学研究所,广东广州510405

出　　处：《今日药学》2015年第9期617-619,共3页Pharmacy Today

基　　金：广东省重大科技专项(2012A080202010);广东省自然科学基金(S2013010012998);广州市科技计划项目(2013J4100088);2012年建设中医药强省立项资助科研课题(20121266;20122004)

摘　　要：目的研究荔枝核有效部位群对α-葡萄糖苷酶抑制作用。方法采用改良的体外α-葡萄糖苷酶抑制剂筛选模型,以阿卡波糖为阳性对照药,分别测定荔枝核醇提取物、荔枝核有效部位群、荔枝核鞣质提取物对α-葡萄糖苷酶的抑制作用。结果荔枝核不同提取物对α-葡萄糖苷酶活性均有较强的抑制作用,在浓度为50 g/L时抑制率分别为63.7%、78.3%、91.5%,阿卡波糖组为67.4%。结论荔枝核有效部位群对α-葡萄糖苷酶活性具有抑制作用,鞣质可能是其主要有效成分。OBJECTIVE To study the inhibition effects of Semen Litchi effective fractions on α-glucosidase. METHODS The inhibition effects of ethanol extracts, effective fractions and tannins of Semen Litchi were determined by improved screening model in vitro for α-glucosidase inhibitors and acarbose served as positive control. RESULTS Different extracts of Semen Litchi both had an obvious inhibition effects on activity of α-glucosidase, while at the concentration of 50 g/L, the inhibitory rate was 63.7%, 78.3%, 91.5%, respectively, and 67.4% for control group. CONCLUSION Semen Litchi effective fractions had inhibition effects on α- glucosidase, tannins may be the effective components of it.

关 键 词：荔枝核 有效部位群 鞣质 Α-葡萄糖苷酶 抑制作用 

分 类 号：R285[医药卫生—中药学]