脑卒中患者神经功能缺损评分与载脂蛋白相关性研究  

Study on correlation between defect scores of nerve function and apolipoprotein in patients with cerebral apoplexy

作　　者：周静茹[1] 孟翠丽[1] 

机构地区：[1]邢台医学高等专科学校生物化学教研室,河北邢台054000

出　　处：《临床和实验医学杂志》2015年第19期1589-1592,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨脑卒中患者神经功能缺损评分与载脂蛋白的相关性。方法检测220例脑卒中患者治疗前的血浆载脂蛋白A1(Apo A1)、血浆载脂蛋白B(Apo B)、脑脊液载脂蛋白E(Apo E)及血浆载脂蛋白H(Apo H)的水平,以及神经功能缺损评分。比较各载脂蛋白前10%和后10%患者临床资料和神经功能缺损评分,并探讨载脂蛋白水平与神经功能缺损评分的相关性。结果 Apo A1前10%和后10%患者间NIHSS评分和梗死面积差异有统计学意义(P<0.05),Apo B前10%和后10%患者间NIHSS评分和梗死面积无统计学差异(P>0.05),Apo E前10%和后10%患者间NIHSS评分和梗死面积差异有统计学意义(P<0.01),Apo H前10%和后10%患者间NIHSS评分无统计学差异(P>0.05),血清Apo A1水平和脑脊液Apo E水平均与NIHSS评分负相关。结论血清中Apo A1和脑脊液中Apo E水平均与NIHSS评分负相关,可以作为判断脑卒中病情和预后的有效指标。Objective To explore the correlation between defect scores of nerve function and apolipoprotein in patients with cerebral apo-plexy. Methods The serum levels of lipid protein A1,apolipoprotein B,cerebrospinal fluid containing apolipoprotein E and plasma apolipopro-tein H were examined in 220 patients with cerebral apoplexy before the treatment,and the clinical data and defect scores of neural function in 10%patients were compared before and after the treatment,and the relationship between their defect scores of neural function and serum levels of apoli-poprotein were compared and evaluated. Results The difference in NIHSS scores and infarct size between serum levels of ApoA1 in 10% patients before and after treatment was statistically significant（ P ﹤ 0. 05）. The difference in NIHSS scores and infarct size between serum levels of ApoB before treatment and after treatment in 10% patients was not significant（ P ﹥ 0. 05）. The difference in NIHSS scores and infarct size between CSF levels of ApoE in 10% patients before and after treatment was statistically significant（ P ﹤ 0. 01）. The difference in NIHSS scores and in-farct size between serum levels of Apo H in 10% patients before and after treatment was not significant（ P ﹥ 0. 05）. The blood level of ApoA1 and CSF level of ApoE were negatively correlated with NIHSS scores. Conclusion The relationship between serum level of ApoA1 and CSF level of ApoE with NIHSS scores showed negative correlation,and they can be used as effective indexes for evaluation of the severity and prognosis of stroke in patients with cerebral apoplexy.

关 键 词：脑卒中 神经功能缺损评分 载脂蛋白 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]