对比两种分期系统在原发性胃肠道恶性淋巴瘤生存预测中的作用  

A comparative study on survival prediction role of TNM staging and Lugano staging in patients with primary gastrointestinal lymphoma

作　　者：姚亚洲[1] 张玲[1] 

机构地区：[1]宝鸡市中心医院血液风湿科,陕西宝鸡721008

出　　处：《临床和实验医学杂志》2015年第19期1603-1606,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的对比分析TNM分期与Lugano分期在原发性胃肠道恶性淋巴瘤生存预测中的作用。方法回顾性分析2006~2010年2月原发性胃肠道恶性淋巴瘤50例临床资料,采用Cox回归分析方法对患者资料进行分析。随访至2015年,统计患者5年生存状况,采用Kaplan Meier方法绘制5年生存曲线。结果随访截止日期为2015年2月,50例患者均随访5年,共11例患者死亡,5年生存率为78.00%。各TNM分期5年生存率：Ⅰ期100%,Ⅱ期83.3%,Ⅲ期62.5%,Ⅳ期25.0%;Lugano分期：Ⅰ期100%,Ⅱ期78.6%,ⅡE期69.2%,Ⅳ期33.3%,两种方法中各分期中患者生存率经比较,差异具有显著性（P〈0.05）。绘制两种分期方法的5年生存曲线,结果显示：TNM分期在各期中的生存曲线更为清晰,Lugano分期生存曲线存在重叠现象。对病理类型发生率较高的弥漫性大B细胞淋巴瘤患者进行两种分期测定5年生存率,TNM分期中4期的5年生存率比较,差异有统计学意义（P〈0.05）,Lugano分期中4期的5年生存率比较,差异无统计学意义（P〉0.05）。结论 TNM分期相对于Lugano分期可更有效地预测原发性胃肠道恶性淋巴瘤患者的5年生存率。Objective To comparatively analyze the survival prediction role between TNM staging and Lugano staging in patients with pri-mary gastrointestinal lymphoma. Methods The clinical data of 50 patients with primary gastrointestinal lymphoma during 2006 to February 2010 were retrospectively analyzed by using Cox regression analysis. The situation of 5 - year survival rate had been statistically analyzed by using Kap-lan Meier method for drawing the 5 - year survival curves. Results The deadline for follow - up was February 2015,all these 50 patients were followed up for 5 years,a total of 11 patients died,hence the 5 - year survival rate was 78. 00% . Among TNM staging for five - year survival rate：100% in stage I,83. 3% in stage II,62. 5% in stage III,and 25. 0% in stage IV. According to Lugano staging：100% in stage I,78. 6% in stage II,69. 2% in stage III,and 33. 3% in stage IV. In comparison with these 2 staging methods,the difference in survival rate was significant （ P ﹤ 0. 05）. The curve drawing of two kinds of staging for 5 - year survival curve showed that TNM staging in the period of survival curve was clearer,the survival curve with Lugano staging was duplicated. A higher incidence of pathological types in patients with diffuse large B - cell lym-phoma,the 5 - year survival rate was measured in two installments,in comparison with 4 stages of five year survival rate byTNM staging,the difference was statistically significant（ P ﹤ 0. 05）. Lugano 5 - year survival rate in four stages,the difference was not statistically significant（ P﹥ 0. 05）. Conclusion The results of measurement are more effective with respect to that of Lugano staging than TNM staging in 5 year survival rate of patients with primary gastrointestinal lymphoma.

关 键 词：原发性胃肠道恶性淋巴瘤 TNM分期 Lugano分期 预测 

分 类 号：R735[医药卫生—肿瘤]