酒依赖患者记忆损害与NMDA受体2B亚基表达的关系研究  被引量:4

Relationship between memory impairment and N-methyl-D-aspartate receptor 2B expression in alcohol dependence patients

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作  者:徐亚辉[1] 王传升[1] 张三强[2] 刘铁桥[3] 郝伟[3] 张瑞岭[1] 

机构地区:[1]新乡医学院第二附属医院成瘾医学科,新乡453002 [2]新乡医学院第二附属医院内科,新乡453002 [3]湘雅二医院精神卫生研究所

出  处:《中华行为医学与脑科学杂志》2015年第9期805-807,共3页Chinese Journal of Behavioral Medicine and Brain Science

基  金:河南省教育厅科学技术研究重点项目(138320222);新乡医学院第二附属医院博士科研启动金

摘  要:目的 探讨洒依赖患者记忆损害的特点,及其与N-甲基-D天冬氨酸(N-methyl-D-aspartate,NMDA)受体2B亚基(NR2B)表达的关系,为临床治疗酒依赖相关的记忆损害提供新的思路.方法 分别采用韦氏记忆量表(Wechsler memory scale,WMS)和逆转录定量PCR(quantitative reverse transcription-poly-merase chain reaction,qRT-PCR)对35例住院治疗的酒依赖患者及32例匹配的正常对照者进行记忆功能评定,采用荧光定量PCR检测NR2B表达水平.结果 与对照组记忆商(memory quotient,MQ)[(69.45±8.96)分]相比,酒依赖病例组MQ[(50.59±8.64)分]显著低于正常对照组(t=-6.08,P<0.01).与对照组NR2B表达水平(1.00±0.00)相比,酒依赖病例组NR2B表达水平(3.52±1.17)升高,差异具有统计学意义(t=9.67,P<0.01).酒依赖患者组MQ与NR2B表达水平呈负相关(r=-0.44,P<0.05).结论 酒依赖患者存在记忆损害,调节NR2B表达水平可能改善酒依赖患者记忆功能.Objective To explore the characteristic of memory impairment and its relationship with Nmethyl-D-aspartate receptor 2B (NR2B) expression in alcohol dependence patients,in order to provide an unprecedented view of alcohol-associated memory impairment therapy.Methods Participants (n=67) included 35 alcohol dependence patients and 32 matched healthy controls.Wechsler memory scale (WMS) was used to access the memory.The expression levels of NR2B were detected with quantitative reverse transcription-polymerase chain reaction (qRT-PCR).Results Compared with the memory quotient(MQ) of controls(69.45±8.96),that of alcohol dependence patients(50.59±8.64) significantly decreased (t=-6.08,P〈0.01).Compared with the NR2B expression level of controls (1.00-0.00),that of alcohol dependence patients (3.52 ± 1.17) significantly increased (t =9.67,P〈0.01).MQ was negatively correlated with the levels of NR2B expression (r=-0.44,P〈0.05).Conclusion Alcohol dependence patients suffer memory impairment detected by WMS,and modulate NR2B expression may improve the memory.

关 键 词:酒依赖 记忆损害 N-甲基-D天冬氨酸2B受体 

分 类 号:R749.62[医药卫生—神经病学与精神病学]

 

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