血液红系参数和胱抑素C联合检测在多发性骨髓瘤患者贫血病变程度判定中的价值  

Study on the significance of blood erythroid parameters and joint detection of cystatin C in observation of the severity of anemia in patients with multiple myeloma

作　　者：饶进[1] 殷莉[1] 林志美[1] 李世云[1] 熊萍[1] 苟小琴[1] 

机构地区：[1]成都大学附属医院血液科,四川成都610081

出　　处：《临床和实验医学杂志》2015年第20期1695-1698,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血液红系参数和胱抑素C（Cys C）联合检测在多发性骨髓瘤患者贫血病变程度判定中的价值。方法选取60例多发性骨髓瘤并贫血的初发住院患者,根据血红蛋白（HGB）水平不同分组,HGB≤60 g/L患者共21例（A组）,HGB 61~89 g/L患者23例（B组）,HGB 90~110 g/L患者16例（C组）。分析各组血液红系参数平均血清血红蛋白（MCH）、平均血球血红蛋白浓度（MCHC）、平均红细胞容积（MCV）、红细胞分布宽度（RDW）及Cys C水平,观察上述各指标与HGB的相关性。结果 A组、B组HGB低于C组,RDW、Cys C水平高于C组（P〈0.05）,A组HGB低于B组（P〈0.05）;RDW、Cys C阳性率A组为85.71%、90.48%,B组为78.26%、82.61%,C组为25.00%、18.75%,A组、B组RDW、Cys C阳性率高于C组阳性率（P〈0.05）。患者HGB与RDW、Cys C水平间Pearson相关性分析呈负相关（P〈0.05）。结论对多发性骨髓瘤初发患者检测血液红系参数RDW及CysC有助于了解患者贫血病变程度变化,贫血改变与RDW、CysC升高关系密切。Objective To explore the combined detection of blood erythroid parameters and cystatin C（ Cys C） in observation of the severity of anemia in patients with multiple myeloma,in order to provide the reference fordifferential diagnosis of multiple myeloma and severity of anemia. Methods A total of 60 cases of multiple myeloma and anemia in hospitalized patients were divided into 2 groups depending on the level of hemoglobin（ HGB）,21 patients with HGB 60 g / L or less were allocated in group A,and 23 patients with HGB 61 ~ 89 g / L in group B,16 patients with HGB 90 ~ 110 g / L in group C,and the analysis of red blood cell parameters as MCH,MCHC,MCV,RDW and change in serum level of Cys C,observe the correlation of the respective index and HGB. Results The level of HGB in groups A and B waslower than that of group C,the levels of RDW and Cys C in group A and group B were higher than those of group C（ P〈0. 05）,the level of HGB in group A was lower than that of group B（ P〈0. 05）; the positive rates of RDW and Cys C in group A,group B and group C were 85. 71% and 90. 48%,78. 26% and 82. 61%,25. 00% and 18. 75% respectively. The positive rates of RDW and Cys C in group A and group B were higher than those of group C（ P〈0. 05）;and Pearson correlation coefficient analysis on levels of RDW and Cys C showed there was a negative correlation between them（ P〈0. 05）. Conclusion In patients with incipient multiple myeloma,the measure of red blood parameters as RDW and change in level of Cys C contributes to understand the severity of anemia in patients with the degree of pathological changes,and the change in anemia is closely correlated with the increase of RDW and Cys C.

关 键 词：多发性骨髓瘤 血红蛋白 平均血球血红蛋白 平均红细胞容积 红细胞分布宽度 胱抑素C 

分 类 号：R733.3[医药卫生—肿瘤]