鼻内镜下切除鼻腔鼻窦神经内分泌癌的临床分析  

Clinical analysis and review of transnasal endoscopic surgery for sinonasal neuroendocrine carcinoma

作　　者：郭涛[1] 孙敬武[1] 汪银凤[1] 

机构地区：[1]安徽省立医院耳鼻咽喉头颈外科,合肥230001

出　　处：《临床耳鼻咽喉头颈外科杂志》2015年第20期1795-1798,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨鼻腔鼻窦神经内分泌癌的临床特点以及内镜下手术切除的效果。方法:回顾性分析5例鼻腔鼻窦神经内分泌癌患者(Kadish分期B期2例,C期3例)的临床资料,治疗采取鼻内镜下切除并联合放化疗(1例因术前肺转移未予手术)。结果:1例无瘤生存5年;1例术后2年局部复发予化疗1年;1例术后1年局部复发再次行鼻内镜手术+化疗;1例2年后肺部转移死亡;1例姑息化疗半年后死亡。结论:本病治疗无统一方案,经鼻内镜手术为主的综合性治疗有效可行,早期的准确诊断和综合治疗是提高生存率的关键。Objective： To study the endoscopic surgery and prognosis of sinonasal neuroendoerine carcinoma. Method：The clinical data of five patients with sinonasal neuroendocrine carcinoma were retrospectively analyzed and the related literatures were reviewed. Two cases were Kadish stage B and three cases were Kadish stage C. Four cases were treated by nasal endoscopic resection combined with postoperative radiotherapy and chemotherapy （one case no surgery for pulmonary metastasis）. Result.. All cases were followed up for six months up to five years. Of 4 cases by combined treatment 1 cases died in 2 years after treatment. One cases survived tumor-free for 5 years and 1 case found local recurrence in 2 years was treated by chemotherapy, 1 case found local recurrence in one year was combined treated （surgery followed by radiotherapy）, 1 case by only chemotherapy died in six months after treatment. Conclusion：There＇s no standard treatment plan. Combined treatment based on transnasal endo- scopic minimally-invasive surgery for nasal-skull base neuroendocrine carcinoma is effective and feasible. The key to improving the survival rate of the disease is early accurate diagnosis and combined treatment.

关 键 词：癌 神经内分泌 鼻窦肿瘤 内镜检查 

分 类 号：R739.62[医药卫生—肿瘤]