金双歧联合含左氧氟沙星和铋剂的四联疗法根除幽门螺杆菌的疗效观察  

Efficacy and safety of Golden Bifid combined with levofloxacin and bismuth-containing quadruple therapy for the eradication of Helicobacter pylori

作　　者：汪再炎 李生[1] 丁百静[1] 

机构地区：[1]皖南医学院附属芜湖市第二人民医院消化内科,安徽芜湖241000

出　　处：《中国微生态学杂志》2015年第10期1174-1176,1180,共4页Chinese Journal of Microecology

摘　　要：目的比较金双歧联合含左氧氟沙星和铋剂四联疗法根除幽门螺旋杆菌(Helicobacter pylori,H.pylori)的疗效。方法纳入180例H.pylori感染患者,随机分为3组:A组给予雷贝拉唑、阿莫西林、克拉霉素、胶体果胶铋治疗;B组给予雷贝拉唑、阿莫西林、左氧氟沙星、胶体果胶铋治疗;C组给予雷贝拉唑、阿莫西林、左氧氟沙星、胶体果胶铋、金双歧治疗。疗程10d。观察各组H.pylori根除率、药物不良反应发生率。结果H.pylori根除率B组(83.3%)和C组(90.0%)高于A组(70.0%),差异有统计学意义(P<0.05);C组(90.0%)高于B组(83.3%),差异有统计学意义(P<0.05)。不良反应发生率A组(31.7%)和B组(30.0%)高于C组(10.0%),差异有统计学意义(P<0.05);A组(31.7%)高于B组(30.0%),但差异无统计学意义(P>0.05)。结论金双歧联合含铋剂四联疗法根除幽门螺杆菌疗效肯定,不良反应小,值得临床推广。Objective To evaluate the efficacy and safety of Golden Bifid combined with levofloxacin and his- muth-containing quadruple therapy for the eradication of Helicobacter pylori. Methods One hundred and eighty patients with H. pylori infection were randomly divided into three groups A, B or C. Group A was treated with Rabeprazole, Amoxicillin, Clarithromycin and Colloidal bismuth pectin, group B was treated with Rabeprazole, Amoxicillin, Levofloxacin, and Colloidal bismuth pectin, and group C was treated with Rabeprazole, Amoxicillin, Levofloxacin, Colloidal hismuth pectin and Golden Bifid. The eradication rate of H. pylori and the incidence of adverse reactions were compared between the three groups. Results The e- radication rates of H. pylori in group B （83.3 %） and group C （90.0% ） were significantly higher than that in group A （70.0%） （P〈0.05） ; the rates of H. pylori eradication in group C （90.0%） were significantly higher than that in group B （83.3%） （P〈0.05）. The incidences of adverse reactions in group A （31.7%） and group B （30.05） were significantly higher than that in group C （10.0%） （P〈0.05）, but there was no significant difference between group A and group B （P〉0.05）. Conclusion Golden Bifid combined with levofloxacin and bismuth-containing quadruple therapy is effective for the treatment of H. pylori infection, with less adverse reactions.

关 键 词：金双歧 四联疗法 幽门螺旋杆菌 感染 

分 类 号：R57[医药卫生—消化系统]