环形RNA研究进展  

Research advances on circular RNAs

作　　者：陈学英[1] 许萍萍[1] 代娟娟[1] 田聆[1] 

机构地区：[1]上海交通大学附属第一人民医院实验中心,上海201620

出　　处：《生命科学》2015年第9期1125-1132,共8页Chinese Bulletin of Life Sciences

基　　金：上海交通大学医学院大学生创新性实验项目(2014059);国家自然科学基金面上项目(81172030)

摘　　要：环形RNA(circular RNA,circ RNA)广泛存在于各种生物细胞中,并且具有结构稳定、表达量丰富以及在不同组织及其不同发育阶段具有表达特异性等特征。目前认为,circ RNA可以在转录后水平调控基因表达,但是circ RNA的产生机制及其代谢途径仍然不是很清楚。迄今研究认为,circ RNA的主要生物学作用是作为微小RNA(micro RNA,miRNA)海绵体调控miRNA的表达。此外,circ RNA在肿瘤、动脉粥样硬化、糖尿病、帕金森病等多种疾病的发生发展中发挥了一定的作用。深入了解circ RNA的作用机制及其功能,有助于深入了解疾病的发生、发展机理,设计更好的预防、诊断和治疗疾病新策略。Circular RNA （circular RNA, circRNA） was in a large number of different species, and they are stable, rich and often show tissue-/developmental-stage-specific expression. However, the detailed mechanisms of their biogenesis and regulation have remained elusive although some evidence suggest that circRNAs regulate gene expression at the post-transcriptional level. The major function of circRNA is considered as microRNA （miRNA） sponges. Currently, circRNAs have been found to be involved in the occurrence, development and progression of human diseases, such as tumor, atherosclerosis, diabetes, and Parkinson＇s disease. To investigate the biogenesis and functions of circular RNAs in depth will help us to find new strategies for the better treatment of those diseases.

关 键 词：环形RNA 微小RNA 微小RNA海绵体 肿瘤 

分 类 号：Q52[生物学—生物化学] R730.231.3[医药卫生—肿瘤]