芳香烃受体与单核-巨噬细胞的关系  

The relationship between aryl hydrocarbon receptor and monocyte-macrophages

作　　者：田李星[1] 张醇[1] 梁华平[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所第一研究室,重庆400042

出　　处：《免疫学杂志》2015年第10期906-910,共5页Immunological Journal

基　　金：国家自然科学基金(81201497)

摘　　要：单核-巨噬细胞具有广泛的生物学功能,是参与固有免疫和适应性免疫的重要细胞。芳香烃受体(arylhydrocarbon receptor,Ah R)作为配体激活的转录因子在免疫应答的过程中有着重要的调节作用。Ah R可在单核-巨噬细胞中表达,并通过与不同配体结合来影响单核-巨噬细胞在机体免疫反应中的作用。通过深入研究Ah R和单核-巨噬细胞在免疫应答中的关系,可为今后纠正单核-巨噬细胞功能紊乱所导致的免疫功能异常提供新的研究方向。本文就Ah R在正常、病理状态下单核-巨噬细胞中的表达及其对功能紊乱单核-巨噬细胞的调节作用做一简要综述。Monocyte-macrophages, having various biological functions, play an important role in innate and adaptive immunity. Aryl hydrocarbon receptor（Ah R）, as a ligand-dependent transcription factor, can combine with various ligands and influence the immune function in monocyte-macrophages of human body. Therefore, the investigation of the relationship between Ah R and monocyte-macrophages would provide a new prospect for the recovery of immune system functional disorder induced by monocyte-macrophages dysfunction. In this paper, we review the expression and regulation of Ah R in normal and dysfunctional monocyte-macrophages.

关 键 词：AHR 单核-巨噬细胞 免疫应答 

分 类 号：R392.12[医药卫生—免疫学]