中国年轻女性乳腺癌临床及病理特征的Meta分析  

Meta analysis of clinical and pathological features of breast cancer in young women in China

作　　者：王婷[1] 廖登辉[1] 王亚冬[1] 甘霖[1] 闵捷[1] 曾真[1] 吕钢[1] 

机构地区：[1]重庆市中医院乳腺甲状腺科,400021

出　　处：《重庆医学》2015年第28期3959-3961,共3页Chongqing medicine

基　　金：重庆市科委前沿与应用基础研究项目(csct2014jcyjA0783)

摘　　要：目的 采用Meta分析方法综合比较中国的年轻女性乳腺癌（≤35岁）与中老年乳腺癌（〉35岁）的临床病理特征。方法 系统地收集中国年轻女性乳腺癌临床病理特征的相关研究文献,并对纳入文献进行质量评价;采用Stata12.0软件进行数据分析,得到合并OR值及其95%CI。结果 纳入合格研究文献31篇,文献质量评价多在6-7分,纳入文献质量较高;年轻乳腺癌和中老年乳腺癌患者之间有统计学差异的临床病理特征为误诊率、临床0-Ⅱ期或Ⅰ-Ⅱ期,病理类型为浸润性癌、组织学Ⅲ级和淋巴结转移阳性,OR值分别为6.42（95%CI：4.22-9.79）、0.61（95%CI：0.50-0.74）、2.25（95%CI：1.69-2.99）、1.73（95%CI：1.23-2.43）、1.80（95%CI：1.23-2.43）。结论 与中老年乳腺癌患者相比,年轻乳腺癌具有误诊率高、临床分期晚、浸润性癌比例高、组织学分化差及易发生淋巴转移的临床病理特点,提示对年轻乳腺癌的筛查和治疗可能应采用不同的原则和措施。Objective To compare the clinical and pathological features of Chinese young breast cancer（age≤35）with elder patients（35）using Meta analysis.Methods Published studies concerning clinical and pathological features of young breast cancer in China were searched systemically and assessed.Stata12.0software was used for data analyzing and calculating ORand its 95%CI.Results Totally 31 studies were selected for Meta analysis,and most of them were classified as 6-7scores,which showed the quality of articles was high.The risk factors of breast cancer and its pooled odds ratio values with statistical significance were as follows 6.42（95%CI：4.22-9.79）,0.61（95%CI：0.50-0.74）when clinical staging of 0-Ⅱ phase orⅠ-Ⅱ phase,2.25（95%CI：1.69-2.99）when histological type of Invasive carcinoma,1.73（95%CI：1.23-2.43）when histological grade of III grade,1.80（95%CI：1.23-2.43）when positive of lymph node metastasis.Conclusion Compared with elder breast cancer,the clinical and pathological characteristics of young breast cancer were mainly for the high misdiagnosis rate,the late clinical stage,the high proportion invasive carcinoma,the poor histological differentiation and the lymph node metastasising easily,the hint of young breast cancer screening and treatment may be different principles and measures should be adopted.

关 键 词：乳腺肿瘤 年轻 临床病理 META分析 

分 类 号：R737.9[医药卫生—肿瘤]