汉族男性注意缺陷多动障碍儿童执行功能与单胺氧化酶A基因活性相关分析  

Correlative analysis between executive function of attention-deficit hyperactivity disorder in Han nationality people and the activity of monoamine oxidase A gene

作　　者：王维千[1] 杜松妹[1] 杨闯[1] 陈宏[1] 赵永忠[1] 梁艳[1] 林海西[1] 张晓燕[1] 王常绿 王美豪[1] 何金彩[1] 

机构地区：[1]温州医科大学附属第一医院精神卫生科,浙江温州325015

出　　处：《温州医科大学学报》2015年第9期641-645,共5页Journal of Wenzhou Medical University

基　　金：浙江省自然科学基金资助项目(LY14H090012);温州市科技局科技计划项目(Y20130163)

摘　　要：目的:探讨单胺氧化酶A(MAOA)基因活性与注意缺陷多动障碍(ADHD)执行功能的关系。方法:采用威斯康星分类测验和Stroop词色干扰测试对37例ADHD汉族儿童与30名正常对照组进行执行功能评估,采集外周全血并应用限制性片段长度多态性的方法检测MAOA基因启动子30 bp可变数目串联重复倍数,根据重复倍数分别将ADHD组和对照组分为高活性组与低活性组。结果:组别因素对WSCT概念化水平、完成分类数、错误应答数、持续错误数、持续应答数的影响差异均有统计学意义(P<0.05);2组间对Stroop色词测验中完成卡片A和卡片C的耗时数差异有统计学意义(P<0.001),干扰效应的耗时数差异有统计学意义(P<O.05);基因活性分组因素对WSCT概念化水平、持续错误数、错误应答数的影响差异有统计学意义(P<O.05),对Stroop色词测验中的完成卡片A和卡片C的耗时数差异有统计学意义(P<0.05),干扰效应的耗时数差异有统计学意义(P<O.05);ADHD组和正常对照组间MAOA等位基因的分布差异均无统计学意义(P>0.05)。结论:本研究未发现MAOA-uVNTR各等位基因分布与ADHD存在关联,但可能与ADHD儿童部分执行功能有一定相关性。Objective：To explore the relationship between polymorphism of MAOA gene activity and the executive function of attention-deficit hyperactivity disorder（ADHD）.Methods：Choose 37 patients who was diagnosed as ADHD and 30 normal volunteers as controls.The executive function was evaluated using Wisconsin card sorting test（WCST） and Stroop test.Taking peripheral blood and restriction fragment length polymorphism（RFLP） techniques were performed to detect MAOA 30 bp tandem repeats multiple of variable number,according to this repeats multiple,the case and control groups were divided into high and low activity group,respectively.Results：Group factor had significant effects on conceptual level,the number of completely classifications,the number of wrong answers,the number of continually mistakes,the number of continually answers in WCST;Group factor also had statistical significant differences on the complete time between A and C card in Stroop test（P〈0.001）,the time of interference effects also had statistically significant（P〈0.05）;MAOA gene activity factor had significant influence on conceptual level,the number of continually mistakes and the number of wrong answers had statistically significant on the difference of complete time in STROOP A card and C card（P〈0.05）,the time of interference effects also had statistically significant（P〈0.05）.There was no statistically significant in allele distribution of MAOA gene between the ADHD cases group and the control group（P〉0.05）.Conclusion：Our study find no relationship between MAOA-uVNTR allele distribution and ADHD,However,there maybe have relationship between MAOA polymorphism and part of the executive function.

关 键 词：注意缺陷多动障碍 单胺氧化A基因多态性 执行功能 Stroop词色干扰测试 威斯康辛分类卡片测验 

分 类 号：R749.94[医药卫生—神经病学与精神病学]