盐酸曲美他嗪在合并糖尿病患者急诊PCI术后的应用探讨  

The application of Trimetazidine Hydrochloride in AMI patients who received emergency PCI operation and complicated with diabetes

作　　者：刘胜全[1] 邢丽娜[1] 伊洪艳[1] 王满庆[1] 黎辉[1] 

机构地区：[1]大庆油田总医院心内科,黑龙江163001

出　　处：《齐齐哈尔医学院学报》2015年第27期4087-4089,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨盐酸曲美他嗪对合并糖尿病患者急诊PCI术后的疗效及安全性。方法将150例合并糖尿病的急性心肌梗死(AMI)患者行急诊PCI后随机分为实验组和对照组,其中实验组75例,对照组75例,对照组常规给予冠心病二级预防药物治疗,观察组在常规治疗组的基础上加用曲美他嗪治疗,两组患者均随访12个月,观察两组患者术后12个月的心血管事件发生率、心肌功能情况、糖化血红蛋白水平及血清肌酐清除率的变化情况。结果观察组术后12个月LVEDD小于对照组、LVEF大于对照组,组间比较差异有显著性(P<0.05)。随访心血管事件总发生率、胸痛及心衰入院发生率明显低于对照组,两组比较差异有显著性(P<0.05),而术后12个月复查血清肌酐清除率和糖化血红蛋白无差别。结论盐酸曲美他嗪应用于合并糖尿病患者急诊PCI术后是安全有效的。Objective To discuss the efficacy and safety of Trimetazidine hydrochloride in the treatment of AMI patients who suffered emergency PCI operation and complicated with diabetes .Methods 150 cases of patients with acute myocardial infarction （ AMI） patients underwent emergency PCI and complicated with diabetes were randomly divided into experimental group and control group , 75 cases in experiment group and 75 cases in the control group .Patients in the control group were given conventional drug treatment for secondary prevention of coronary heart disease , however , the patients in observation group were given Trimetazidine on the basis of conventional treatment , patients of both groups were followed up for 12 months.Occurrence rate of cardiovascular event , changes of myocardial function , the level of glycosylated hemoglobin and serum creatinine clearance rate of the two groups were observed .Results In the observation group , after 12 months, LVEDD was less than that of the control group , on the contrast the LVEF was greater than the control group , and there was significant difference between the two groups （P〈0.05）.The total incidence of cardiovascular events , chest pain and heart failure caused hospitalization in experimental group was significantly lower than the control group , there were significant difference between the two groups （P〈0.05）.And the differences of serum creatinine clearance rate and glycosylated hemoglobin between the two groups were not statistically significant on 12 months after operation . Conclusions The application of Trimetazidine hydrochloride in AMI patients received PCI surgery and complicated with diabetes is safe and effective .

关 键 词：曲美他嗪 糖尿病 急性心肌梗死 PCI 心肌保护 

分 类 号：R914.5[医药卫生—药物化学]