甲状腺功能异常与乳腺良恶性肿瘤关系探讨  

Investigate The Relationship Between Abnormal Thyroid Function and Benign or Malignant Breast Tumors

作　　者：胡悦[1] 孙超 地力木拉提.艾斯木吐拉 栾梅香[1] 

机构地区：[1]新疆医科大学第一附属医院乳腺外科 [2]新疆维吾尔自治区昌吉市吉木萨尔县69241部队卫生队

出　　处：《中国普外基础与临床杂志》2015年第10期1240-1243,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨甲状腺功能异常与乳腺良恶性肿瘤的关系。方法采用化学发光法分别检测563例乳腺良性肿瘤患者、87例乳腺癌患者和123例健康人群(正常对照)血清中游离三碘甲腺原氨酸(FT3)、三碘甲腺原氨酸(T3)、甲状腺素(T4)、游离甲状腺素(FT4)、促甲状腺素(TSH)、抗甲状腺球蛋白抗体(Anti-TG)和抗甲状腺过氧化物酶抗体(Anti-TPO)的含量。结果乳腺癌患者血清中T3及T4含量较正常对照组和乳腺良性肿瘤组低(P<0.05),但FT3、FT4及TSH水平3组间差异均无统计学意义(P>0.05)。Anti-TG与Anti-TPO表达阳性率较乳腺良性肿瘤组及正常对照组高(P<0.001)。乳腺癌患者血清中T3及T4含量与ER和PR的表达无关;在Her-2阴性表达和有淋巴结转移者T3及T4含量相对较低(P<0.05)。结论 Anti-TG与Anti-TPO表达阳性以及T3和T4含量的降低可为预测乳腺癌发病提供依据。Objective To investigate the correlation between abnormal thyroid function and benign or malignant breast tumors. Methods The contents of free iodine three original acid （FT3）, three iodine original acid （T3）, thyroxine （T4）, free thyroxine （FT4）, thyroid-stimulating hormone （TSH）, anti-thyroglohulin antibodies （Anti-TG）, and anti- thyroid peroxidase antibody （Anti-TPO） were detected by chemiluminescence method in 563 patients with benign breast neoplasms, 87 patients with breast cancer, and 123 health examination population. Results T3 and T4 levels in patients with breast cancer were lower than those of normal control group and benign tumor group （P〈0.05）. However, there were no significant difference in the levels of FT3, FT4, and TSH between the 3 groups （P〉0.05）. The positive rates of Anti- TPO and Anti-TG were higher than those of benign group and normal group （P〈0.001）. T3 and T4 levels in patients with breast cancer were not related to the expression of ER and PR, in Her-2 negative expression and lymph node metastasis were relatively low （P〈0.05）. Conclusion The decrease of contents of T3 and T4, and the positive expressions of Anti- TPO and Anti-TG may provide a basis for predicting the incidence of breast cancer.

关 键 词：乳腺癌 乳腺良性肿瘤 甲状腺功能异常 

分 类 号：R737.9[医药卫生—肿瘤] R581[医药卫生—临床医学]