FoxQ1在食管鳞状细胞癌中的表达及其与预后  

Expression and prognosis of FoxQ1 in esophageal squamous cell carcinoma

作　　者：姚宁华[1] 盖领[2] 黄华[3] 袁心露[4] 王新[5] 

机构地区：[1]南通大学附属医院肿瘤放疗科,江苏南通226001 [2]南通大学附属医院肿瘤化疗科,江苏南通226001 [3]南通大学附属医院肿瘤病理科,江苏南通226001 [4]南通大学附属医院内分泌科,江苏南通226001 [5]南通大学神经再生研究所,江苏南通226001

出　　处：《临床与病理杂志》2015年第9期1632-1636,共5页Journal of Clinical and Pathological Research

摘　　要：目的:研究Fox Q1在食管鳞状细胞癌组织中的表达及其与临床病理特征和预后的关系。方法:在组织水平,应用免疫组织化学En Vision法检测91例食管鳞状细胞癌组织及相应癌旁组织Fox Q1的表达,并分析其表达与临床病理特征及预后之间的关系。结果:1)Fox Q1在食管鳞状细胞癌组织及配对正常食管组织中的阳性表达率分别为:62.6%(57/91)和23.1%(21/91),差异有统计学意义(P<0.05);Fox Q1的表达与肿瘤浸润深度、临床分期及预后相关(P<0.05)。经Kaplan-Meier法生存比较,Fox Q1的阳性表达者比阴性表达者生存期短(P<0.05);多因素Cox比例风险模型分析显示,Fox Q1可以作为判断食管鳞状细胞癌预后的独立因素(P<0.05)。结论:Fox Q1在食管鳞状细胞癌组织中高表达,其表达水平与食管鳞癌发生发展及预后密切相关。有望成为评估食管鳞状细胞癌预后的有效指标。Objective：To investigate the expression of FoxQ1 in esophageal squamous cell carcinoma （ESCC） and analyze their clinical signiifcance, and to evaluate the correlation with prognosis. Methods：Immuno-histochemical method was used to detect the expression of FoxQ1 in 91 cases of ESCC tissues and adjacent normal esophageal tissues.χ2 test was used to analyze their correlations with the clinicopathologic factors and prognosis of ESCC patients. Results：hTe expression of FoxQ1 was signiifcantly higher in ESCC than that in normal esophageal tissues （62.6%vs 23.1%, P〈0.05）. FoxQ1 expression had signiifcantly correlations with invasive depth, clinical stage and prognosis （P〈0.05）. hTe results of Kaplan-Meier survival analysis indicated that positive expression of FoxQ1 were associated with a worse survival （P〈0.05）. Conclusion：FoxQ1 was highly expressed in ESCC and signiifcantly correlated with prognosis of esophageal cancer;FOXQ1 might be an indicator to predict the prognosis in esophageal cancer.

关 键 词：食管鳞状细胞癌 FoxQ1 预后 

分 类 号：R735.1[医药卫生—肿瘤]