新疆酒依赖共病双相情感障碍患者冲动攻击行为与单胺氧化酶A基因多态性关联分析  

Association between polymorphism of monoamine oxidase A gene and aggressive behavior in alcohol-dependent patients combined with bipolar affective disorder in Xinjiang

作　　者：赵宗峰[1] 邹韶红[2] 赵志强 佟钙玉[2] 徐向东 董红斌 

机构地区：[1]新疆维吾尔自治区人民医院科研教育中心,乌鲁木齐830001 [2]新疆维吾尔自治区人民医院临床心理科,乌鲁木齐830001 [3]新疆精神卫生中心戒酒科,乌鲁木齐830002

出　　处：《中华实用诊断与治疗杂志》2015年第10期961-963,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：新疆维吾尔自治区自然科学基金(2013211A107)

摘　　要：目的 探讨单胺氧化酶A（monoamine oxidase A,MAOA）基因rs1137070位点基因多态性与新疆汉族和维吾尔族（维族）酒依赖共病双相情感障碍患者冲动攻击行为之间的关系。方法 424例酒依赖共病双相情感障碍患者,汉族230例,维族194例;根据有无施暴行为分为施暴组240例和无施暴组184例。采用PCR产物直接测序法检测汉族和维族2组MAOA基因rs1137070位点多态性,分别比较汉、维族2组等位基因频率的分布情况,分析基因多态性与冲动攻击行为的关系。结果 汉族和维族施暴组C等位基因频率（57.8%、69.9%）均高于无施暴组（39.2%、53.7%）,T等位基因频率（42.2%、30.4%）均低于无施暴组（60.8%、46.3%）（P〈0.05）;汉族和维族施暴组施暴风险分别是无施暴组的2.124倍（OR=2.124,95%CI：1.250~3.609,P=0.005）和1.981倍（OR=1.981,95%CI：1.096~3.582,P=0.023）。结论 新疆酒依赖共病双相情感障碍患者冲动攻击行为与MAOA基因rs1137070位点基因多态性可能有关联性。Objective To explore the association between monoamine oxidase A （MAOA） gene polymorphism and aggressive behavior in Han and Uygur alcohol-dependent patients combined with bipolar affection disorder in Xinjiang. Methods A total of 424 alcohol-dependent patients combined with bipolar affection disorder including 230 Han and 194 Uygur patients were divided into violence group （n=240） and nonviolence group （n= 184）. The techniques of PCR and DNA sequencing were used to detect rs1137070 single nueleotide polymorphism loci of MAOA gene to compare the distribution of the frequency of alleles between Han and Uygur patients. The association between the polymorphisms and aggressive behavior was analyzed. Results The frequencies of Callele o{ rs1137070 in Han and Uygur violence groups （57.8%, 69. 9%） were significantly higher than those in nonviolence groups （39. 2%, 53. 7%） （P〈0.05）. The frequencies of T allele gene were lower in Han and Uygur violence groups （42. 2%, 30. 4%） than those in Han and Uygur nonviolence groups （60.80/, 46.30/） （P〈0.05）. The risks of violence were 2. 124 and 1. 981 times higher in HanandUygur violence groups （OR=2. 124, 95%C1： 1. 250 to 3. 609, P=0.005; OR=1. 981, 95%CI： 1.096 to 3. 582, P= 0. 023） than those in nonviolence groups. Conclusion MAOA rs1137070 gene polymorphism may be associated with aggresive behavior in Han and Uygur alcohol-dependent patients combined with bipolar affective disorder in Xinjiang.

关 键 词：酒依赖共病双相情感障碍 冲动攻击行为 单胺氧化酶A 单核苷酸多态性 

分 类 号：R749.62[医药卫生—神经病学与精神病学]