含硅二烃基锡(Ⅳ)的2-巯基苯并噻唑配合物的合成、结构及抗癌活性  

Synthesis, Characterization and Antitumour Activity of Diorganotin(Ⅳ) Complexes Containing Silicon of 2-Mercaptobenzothiazole

作　　者：廖启华[1] 林森[1] 邓瑞红[1] 黄志强[1] 邓柯玉 严兆华[1] 

机构地区：[1]南昌大学化学系,南昌330031 [2]南昌大学医学院,南昌330031

出　　处：《有机化学》2015年第9期1923-1928,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20762006)资助项目~~

摘　　要：合成了6个含硅二烃基锡(IV)的2-巯基苯并噻唑配合物R1R2Sn L2(R1=Me3Si CH2,R2=Me3Si CH2或Ph,Cy;R1=Et Me2Si CH2,R2=Et Me2Si CH2或Ph,Cy.LH=2-硫基苯并噻唑),并通过IR、1H NMR、13C NMR、元素分析和X射线单晶衍射对目标化合物进行结构表征.结果表明,配体L以硫醇互变异构体形式与锡原子配位,形成了以锡为中心的六配位扭曲八面体结构;生物活性试验的初步结果显示,含硅二烃基锡(IV)-2-巯基苯并噻唑对肺腺癌细胞(A549)具有较强的体外抗癌活性.Six diorganotin（IV） complexes containing silicon of 2-mercaptobenzothiazole R1R2Sn（L）2（R^1=Me3SiCH2, R^2=Me3SiCH2 or Ph, Cy; R^1=Et Me2SiCH2, R^2=EtMe2SiCH2 or Ph, Cy. LH=2-mercaptobenzothiazole） have been synthesized and characterized by ^1H NMR, ^13 C NMR, IR, elemental analysis and X-ray single-crystal study. The results showed that ligand L acts as thiol tautomerism coordinating with tin atom, and thus the central tin atom was six coordinated in distorted octahedral geometry. The preliminary bioassay tests showed that diorganotin complexes of 2-mercaptobenzothiazole have a good antitumor activity in vitro against A-549.

关 键 词：二烃基锡 2-巯基苯并噻唑 配合物 合成 结构 抗癌活性 

分 类 号：O641.4[理学—物理化学]