mTOR在脂质稳态中的作用及运动调节  

Functions of mTOR in Lipid Homeostasis and Exercise-Related Regulation

作　　者：张庆[1,2,3] 漆正堂[1,3] 丁树哲[1,3] 

机构地区：[1]华东师范大学"青少年健康评价与运动干预"教育部重点实验室,上海200241 [2]法国里昂高等师范学院分子细胞生物学实验室,法国里昂69364 [3]华东师范大学体育与健康学院,上海200241

出　　处：《武汉体育学院学报》2015年第10期69-75,共7页Journal of Wuhan Sports University

基　　金：国家自然科学基金项目(31171142)

摘　　要：哺乳动物雷帕霉素靶蛋白(mechanistic or mammalian target of rapamycin,mTOR)信号通路可以整合营养、能量、生长因子、运动等多种细胞外信号,调节众多的代谢和生理过程,如基因转录、蛋白质翻译、核糖体合成、脂质稳态等。对近期mTOR脂质稳态调节的研究进行文献综述,着重综述mTOR在脂解、脂肪生成以及脂肪细胞形成中的重要作用,同时探讨运动对mTOR的作用效应。以期对将来研究运动通过mTOR影响脂质稳态提供理论支持、加深对脂质稳态变化引起的相关疾病的理解、促进更合理的运动处方建议以及靶向药物的研发提供帮助。The mechanistic or mammalian target of rapamycin （roTOR） signahng pathway can integrate mumpie extracel- lular signals including nutrition, energy, growth factors and exercise to regulate numerous metabolic and physiological processes, such as gene transcription, protein translation, ribosome biogenesis and lipid homeostasis. This review ex- plores recent findings on the role of mTOR in lipid homeostasis, with an emphasis on lipolysis, lipogenesis, and adipogen- esis, also discusses the effects of exercise on mTOR. The purpose is to provide theoretical supports for future study on the effects of exercise on lipid homeostasis via mTOR, deepen understanding of lipid homeostasis related diseases, pro- mote more reasonable exercise prescriptions and targeted drug research and development.

关 键 词：MTOR 脂质稳态 运动 生物医学 运动人体科学 

分 类 号：G804.7[文化科学—运动人体科学]