控制性促排卵周期获卵数的调控  

Regulation of number of oocytes retrieved in controlled ovarian stimulation

作　　者：陈圆辉 徐晓航[1,2] 张翠莲[1,2] 

机构地区：[1]河南省人民医院 [2]郑州大学人民医院生殖医学中心,郑州450003

出　　处：《生殖医学杂志》2015年第10期798-802,共5页Journal of Reproductive Medicine

基　　金：郑州市科技创新团队项目(113PCXTD435)

摘　　要：在体外受精-胚胎移植(IVF-ET)控制性卵巢刺激(COS)过程中,获得适当数量及高质量的卵母细胞是减少甚至避免卵巢过度刺激综合征(OHSS)的发生及优化妊娠结局的关键。目前,多认为获卵超过15个时OHSS风险增加的同时对妊娠结局并无明显改善,但对于最适获卵数的具体界定,目前尚无共识。COS过程中对获卵数的调控,主要从卵巢功能的评估、促排卵方案的合理选择,及促排卵过程中促性腺激素(Gn)启动剂量、对优势卵泡群的调控和诱发排卵策略的选择等方面进行。总体而言,COS过程中要对患者的情况进行充分评估,制定个体化治疗方案,从多方面对获卵数加以调控。The proper number of oocytes with high quality is the key point to optimize the pregnancy outcome,and reduce or even avoid occurrence of ovarian hyperstimulation syndrome（OHSS）during controlled ovarian stimulation（COS）.At present time,the most studies indicate if oocytes retrieved are more than fifteen it would increase the risk of OHSS and does not improve clinical pregnancy rate and live birth rate.However,the consensus on the optimum oocyte number has not been reached.The regulation strategies of oocyte number include the assessment of ovarian reserve,properly choosing protocol of COS,using appropriate starting dosage of gonadotropin and trigger strategy,et al.Overall,the patient＇s condition should be fully assessed in order to formulate the individual strategy during COS process,and it is necessary to regulate the oocyte number from various aspects.

关 键 词：控制性卵巢刺激 获卵数 调控 个体化 

分 类 号：R[医药卫生]