富组氨酸糖蛋白基因多态性与中国妇女卵巢反应性的相关性初探  

Polymorphism of histidine-rich glycoprotein affected ovarian response in Chinese women:apilot study

作　　者：金白灵 牛志宏[1] 冯云[1] 

机构地区：[1]上海交通大学附属瑞金医院生殖中心 [2]上海交通大学医学院瑞金临床医学院,上海200024

出　　处：《生殖医学杂志》2015年第10期850-854,共5页Journal of Reproductive Medicine

摘　　要：目的探讨中国妇女富组氨酸糖蛋白(histidine-rich glycoprotein,HRG)基因C633T多态性与超排卵周期中卵巢对促性腺激素反应性的相关性。方法纳入107名接受体外受精辅助生育的女性,用测序法检测基因型,统计不同基因型患者超排卵周期结局。结果 HRG基因C633T位点C/C、C/T、T/T基因型频率分别为30.0%、64.4%、5.6%,各基因型患者的年龄、体重指数(BMI)、基础性激素水平、窦卵泡数无显著差异,而T/T基因型患者的平均获卵数9.7枚,显著低于C/T组(14.6枚)与C/C组(14.5枚);比较受精卵数(T/T vs.C/T vs.C/C为6.1vs.10.2vs.11.0)及优质胚胎数(T/T vs.C/T vs.C/C为3.0vs.7.0vs.7.4),T/T基因型患者同样显著低于另外两种基因型(P均<0.05)。结论 HRG基因C633T多态性可能影响卵巢反应性、卵母细胞质量及受精卵发育。Objective：To investigate the relationship between HRG C633 TSNP and the ovarian response.Methods：Genotype of 107 women undergoing ovarian stimulation prior to IVF was detected by PCR and sequencing analysis.The stimulation outcomes were analyzed and compared in these women.Results：The frequency of C/C,C/T,T/T genotypes in this study were 30.0%,64.4% and 5.6%respectively.There were no differences in age,body mass index（BMI）,basal hormone level or antral follicle count between the three different genotypes groups.The T/T genotype obtained significantly fewer oocytes,fertilized oocytes and good-quality embryos than the other two genotypes.Conclusions：HRGC633TSNP might influence ovarian response,oocyte quality and embryo development.

关 键 词：HRG基因 多态性 卵巢反应性 

分 类 号：R[医药卫生]