外周血microRNAs在结直肠癌诊疗中的应用及检测方法进展  

The application for diagnosis and treatment and the progress for detection methods of circulating ndcroRNAs in colorectal cancer

作　　者：刘维薇[1] 胡婷婷[2] 关明[2] 

机构地区：[1]同济大学附属上海市第十人民医院检验科,200072 [2]复旦大学附属华山医院检验科

出　　处：《中华检验医学杂志》2015年第10期653-656,共4页Chinese Journal of Laboratory Medicine

基　　金：基金项目：上海市卫生局优秀青年人才培养计划（XYQ2013095）;国家自然科学基金（81370067,81572061）

摘　　要：microRNAs作为新型肿瘤诊疗检测指标对肿瘤的早期筛查及鉴别诊断具有重要的临床价值，特别是外周血microRNAs检测因其低侵人性和高灵敏度，临床应用前景广阔。本文分析了近年来外周血microRNAs在结直肠癌诊疗中的应用，同时也对microRNAs作为肿瘤标志物在临床应用中存在的问题，特别是众多影响因素所致的检测结果不稳定等制约其发展的主要原因进行了探讨。microRNAs as novel tumor biomarkers exert important clinical value in early screening and antidiastole of human cancers. They show a broad prospect in clinical application, particularly due to their low invasive and high sensitivity. This review focused on the application of circulating microRNA for diagnosis and monitoring treatment in colorectal cancer based on the recent findings. Meanwhile, the defects in clinical practice by using microRNAs as tumor biomarkers and the major causes which could constraint their application, especially the unreliable detection result caused by many factors, have been discussed.

关 键 词：结直肠肿瘤 微RNAS 肿瘤标记 生物学 

分 类 号：R735.34[医药卫生—肿瘤] R730.43[医药卫生—临床医学]