Prodynorphin Gene Promoter Polymorphism and Temporal Lobe Epilepsy:A Meta-analysis  

作　　者：张娜 欧阳陶辉 周青 康慧聪 朱遂强 

机构地区：[1]Department of Neurology,Tongji Hospital,Huazhong University of Science and Technology [2]Department of Neurosurgery,Tongji Hospital,Huazhong University of Science and Technology

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2015年第5期635-639,共5页华中科技大学学报（医学英德文版）

基　　金：supported by the National Natural Science Foundation of China for Young Scholars(No.81201006)

摘　　要：Previous studies have reported the association of prodynorphin（PDYN） promoter polymorphism with temporal lobe epilepsy（TLE） susceptibility,but the results remain inconclusive. To further precisely evaluate this association,we performed a meta-analysis. Published studies of TLE and PDYN polymorphism up to February 2015 were identified. Subgroup analysis by TLE subtype was performed. Moreover,sensitivity,heterogeneity,and publication bias were also analyzed. Seven case-control studies were finally included in this meta-analysis with 875 TLE cases and 1426 controls. We did not find synthetic evidence of association between PDYN promoter polymorphism and TLE susceptibility（OR=1.184,95% CI： 0.873–1.606,P=0.277）. Similar results were also obtained in non-familial-risk TLE subgroup. However,in the familial-risk TLE subgroup analysis,a significant association was observed（OR=1.739,95% CI： 1.154–2.619,P=0.008）. In summary,this meta-analysis suggests that PDYN gene promoter polymorphism might contribute to familial-risk TLE.Previous studies have reported the association of prodynorphin（PDYN） promoter polymorphism with temporal lobe epilepsy（TLE） susceptibility,but the results remain inconclusive. To further precisely evaluate this association,we performed a meta-analysis. Published studies of TLE and PDYN polymorphism up to February 2015 were identified. Subgroup analysis by TLE subtype was performed. Moreover,sensitivity,heterogeneity,and publication bias were also analyzed. Seven case-control studies were finally included in this meta-analysis with 875 TLE cases and 1426 controls. We did not find synthetic evidence of association between PDYN promoter polymorphism and TLE susceptibility（OR=1.184,95% CI： 0.873–1.606,P=0.277）. Similar results were also obtained in non-familial-risk TLE subgroup. However,in the familial-risk TLE subgroup analysis,a significant association was observed（OR=1.739,95% CI： 1.154–2.619,P=0.008）. In summary,this meta-analysis suggests that PDYN gene promoter polymorphism might contribute to familial-risk TLE.

关 键 词：Epilepsy epilepsy familial Promoter promoter susceptibility Polymorphism subgroup heterogeneity Seven 

分 类 号：R742.1[医药卫生—神经病学与精神病学]