胃铋镁联合三联疗法治疗幽门螺杆菌阳性十二指肠球部溃疡的效果  

Effect of Compound Bismuth and Magnesium Granules combined with triple therapy for treatment of Hp positive duodenal bulbar ulcer

作　　者：王经荣[1] 郑梅英[1] 

机构地区：[1]福建省石狮市医院消化内科,福建石狮326700

出　　处：《中国医药导报》2015年第29期112-115,共4页China Medical Herald

摘　　要：目的 观察胃铋镁联合雷贝拉唑、克拉霉素、阿莫西林治疗幽门螺杆菌（Hp）阳性十二指肠球部溃疡的临床效果。方法 收集2013年10月-2014年10月石狮市医院收治的98例Hp感染阳性的十二指肠球部溃疡患者,将其随机分为治疗组和对照组,各49例。治疗组给予胃铋镁颗粒、雷贝拉唑、克拉霉素、阿莫西林,对照组给予胶体果胶铋、雷贝拉唑、克拉霉素、阿莫西林。两组均口服14 d后,继续口服雷贝拉唑14 d。观察两组患者症状缓解、溃疡愈合及复发、Hp根除率、复发率以及药物不良反应情况。结果 治疗组用药第2天消化道症状缓解率（81.63%）明显高于对照组（57.44%）,差异有统计学意义（P〈0.05）。治疗组无因不良反应而终止治疗者,对照组2例患者因不良反应终止治疗,治疗组与对照组不良反应发生率分别为6.12%、25.53%,差异有统计学意义（P〈0.05）。疗程结束后4周,两组溃疡愈合率和Hp根除率比较差异均无统计学意义（P〉0.05）;疗程结束后半年,治疗组溃疡复发率、Hp复发率低于对照组,但差异无统计学意义（P〉0.05）。结论 胃铋镁四联疗法在临床上治疗Hp阳性十二指肠球部溃疡能缓解患者消化道症状,提高患者依从性,减少药物不良反应,降低溃疡复发和Hp再感染的风险,在治疗消化性溃疡上具有一定的优势及较好的安全性。Objective To observe the clinical effect of Compound Bismuth and Magnesium Granules combined with Rabeprazole, Clarithromycin and Amoxicillin for treatment of Hp positive duodenal bulbar ulcer. Methods 98 patients with Hp positive duodenal bulbar ulcer admitted to Shishi Hospital from October 2013 to October 2014 were selected and randomly divided into treatment group and control group, with 49 cases in each group. The treatment group was given Compound Bismuth and Magnesium Granules, Rabeprazole, Clarithromycin, Amoxicillin; the control group was given Colloidal Bismuth Pectin, Rabeprazole, Clarithromycin, Amoxicillin; the two groups were treated with oral administration for 14 days, then with oral Rabeprazole for another 14 days. The remission of symptoms, ulcer healing or recurrence, Hp eradication or recurrence rates, adverse drug reactions of the two groups were observed. Results The second day when medicine was taken, gastrointestinal symptoms remission rate of the treatment group（81.63%） was significantly higher than that of control group（57.44%）（P〈0.05）. There were no terminate treatments because of adverse drug reactions in the treatment group, while there were 2 cases in the control group; the incidence of adverse drug reactions of treatment group and control group was 6.12%, 25.53% respectively, the difference was statistically significant（P〈0.05）. Furthermore, 4 weeks after the end of treatment, both ulcer healing and Hp eradication rates of the two groups had no statistically significant differences（P〉0.05）; and half a year after the end of treatment, the recurrence rates of ulcer and Hp in the treatment group were lower than those of control group, with no statistically significant differences（P〉0.05）. Conclusion Compound Bismuth and Magnesium Granules quadruple therapy in the treatment of Hp positive duodenal bulbar ulcer can relieve digestive tract symptoms, improve compliance of patients, reduce adverse drug reactions, decrease the risk of recurrence of peptic ulce

关 键 词：十二指肠球部溃疡 HP根除 胃铋镁颗粒 四联疗法 胶体果胶铋 

分 类 号：R573.1[医药卫生—消化系统]