A型肉毒毒素治疗局限性肌张力障碍和肌肉痉挛的临床效果观察  

The clinical effect of botulinum toxin A for treatment of localized muscular tension disorder and muscle spasm

作　　者：丛培刚 邵威丽 

机构地区：[1]山东省威海市文登区人民医院,山东威海264400

出　　处：《转化医学电子杂志》2015年第7期54-55,共2页E-Journal of Translational Medicine

摘　　要：目的：研究分析A型肉毒毒素治疗局限性肌张力障碍和肌肉痉挛的临床效果．方法：将我院2011-01／2012-04接收治疗的241例局限性肌张力障碍和肌肉痉挛患者作为研究分析对象，将两组患者随机分为研究组（ n＝120）和对照组（ n＝121）．其中包含118例侧面肌痉挛，64例痉挛性斜颈，59例口下颌肌张力障碍．两组给予不同的治疗方式，随访时间为2～28个月，将两组患者的治疗效果和患者满意度进行比较．结果：治疗后，研究组中120例患者118例得到有效治疗，治疗总有效率为98．33％，对照组中121例患者100例得到有效治疗，治疗总有效率为82．64％．将两组患者的治疗有效率进行比较，数据存在统计学意义（P＜0．05）．比较两组患者治疗满意度，研究组（97．50％）明显优于对照组（85．12％），差异具有统计学意义（P＜0．05）．结论：治疗局限性肌张力障碍和肌肉痉挛采用注射A型肉毒毒素的方式，可有效提高治疗疗效，改善医患关系，从而提高患者的满意度．AIM:To study the clinical effect of botulinum toxin A for the treatment of localized muscular tension disorder and muscle spasm. METHODS: A total of 241 cases of limited dystonia and muscle spasm patients admitted from January 2011 to April 2012 in our hospital were randomly divided into study group and control group,with 120 cases in the study group and 121 cases in the control group. Among these cases, there are 118 cases of hemifacial spasm,64 cases of spasmodic torticollis and 59 cases of oromandibular dystonia. The two groups were treated with different methods and followed up for 2 months to 28 months. And the treatment effect of the two groups were compared with patients ’ satisfaction. RESULTS:A total of 120 cases of patients in study group were treated effectively after the treatment, and the total efficiency was 98. 33%, while 100 patients in the control group were treated effectively after the treatment,and the total efficiency was 82.64%. The effective rate of the two groups were significantly different ( P<0.05) . The treatment satisfaction in the study group (85.12%) were significantly better than it in the control group (97.50%),and the data were significantly different (P<0.05). CONCLUSION:Application of botulinum toxin A in the treat?ment of the patients with localized muscle tension and muscle spasm,can effectively improve the treatment effect and improve the relationship between doctors and patients, which can effectively improve patients’ satisfaction.

关 键 词：A型肉毒毒素 张力障碍 肌肉痉挛 

分 类 号：R746[医药卫生—神经病学与精神病学]