链霉蛋白酶稀释浓度与服用时间对胃镜检查质量的影响  

Effects of dilute concentration and acting time of pronase on gastroscopy

作　　者：巫织娥[1] 顾华英[1] 梁艳娉[1] 黄晓丽[1] 杨逸冬[1] 陶金[1] 吴斌[1] 

机构地区：[1]中山大学附属第三医院消化内镜中心,广州510630

出　　处：《中华消化内镜杂志》2015年第10期673-677,共5页Chinese Journal of Digestive Endoscopy

摘　　要：目的研究链霉蛋白酶不同稀释浓度与不同服用时间对胃镜检查质量的影响。方法对448例无痛胃镜检查患者，随机分为121服链霉蛋白酶组与对照组，每组内按胃镜检查前不同服用时间（10、20、30、60、120min）分成5个亚组。链霉蛋白酶分别稀释成50ml（400U／m1）与100ml（200U／m1），对照组仅服用等量的稀释液。在无痛胃镜检查过程中，分别记录其对镜下视野清晰度、检查时间及病灶发现率等指标的影响。结果链霉蛋白酶组内镜下视野清晰度显著高于对照组，且内镜检查时间少于对照组（P〈0．05）。胃镜检查前20、30与60min服用镜下视野清晰度均达80％以上，3个时间点间差异无统计学意义（P〉0．05），服用超过30min，尤其是60min后视野清晰度明显下降。服用稀释成50ml和100ml的链霉蛋白酶溶液对内镜检查视野清晰度差异无统计学意义（P=0．640）。结论胃镜检查前服用链霉蛋白酶可提高内镜检查视野清晰度、减少检查时间、提高微小病灶检出率，胃镜检查前20～60min服用稀释成50ml或100ml的链霉蛋白酶对视野清晰度、检查时间、微小病灶检出率差异并无统计学意义。Objective To investigate the effects of dilute concentration and acting time of pronase on quality of gastroscopy. Methods A total of 448 patients were randomly divided into two groups ： sodium bicarbonate group and pronase with sodium bicarbonate group. Pronase was diluted into 50 ml （400 U/ml） and 100 ml （200 U/ml） using sodium bicarbonate. The patients were pretreated by pronase of different con- centrations 10 min, 20 min, 30 min, 60 min and 120 rain before gastroscopy. Diluent of same quantity were taken by the control group. Visibility of gastroscopy, procedure times and positive rates of lesions were com- pared. Results Pretreatment of pronase significantly improved visibility of gastroscopy, raised positive rates of lesions, and reduced procedure times of gastroscopy, compared with the control group （ each P 〈 0. 05 ）. The visibility of gastroscopy were over 80% 20,30, and 60 minutes before the examination with no significant difference （ P 〉 0. 05 ）. The visibility of gastroscopy decreased sharply 30 minutes after taking pronase, especially after 60 minutes. There was no significant difference in the quality of gastroscopy between the 200 U/ml and 400 U/ml group 20-60 minutes before gastroscopy （ P = 0. 640 ）. Conclusion Pronase （200 U/ml-400 U/ml） significantly improves visibility of gastroscopy, raises positive detection rates of le- sions, and reduces procedure time of gastroscopy 20-60 minutes before pretreatment.

关 键 词：链霉蛋白酶 稀释浓度 胃镜检查 质量 

分 类 号：R57[医药卫生—消化系统]