陕西省不同年龄段妇女人乳头状瘤病毒感染现状及亚型分布  

Analysis of human papillomavirus infection and subtypes in different age stages＇ woman cases in Shaanxi province

作　　者：李军[1] 王一羽[1] 田小飞 南星[1] 阎涛 王国庆 付玉兰 王平 原荣[1] 魏曙亚 侯蓉[1] 郭晓英[1] 

机构地区：[1]西安交通大学医学院附属陕西省肿瘤医院基础研究中心,710061 [2]陕西省妇科肿瘤中心

出　　处：《国际流行病学传染病学杂志》2015年第5期297-300,共4页International Journal of Epidemiology and Infectious Disease

基　　金：陕西省科技计划（2011K15-06-09）

摘　　要：目的了解陕西省不同年龄段妇女人群HPV感染状况及亚型分布特征，为该地区宫颈癌防治提供参考依据。方法采用PCR体外扩增和DNA反向点杂交技术，对28671例妇女的宫颈脱落细胞样本进行HPV基因分型检测。结果HPV总感染率为16．52％（4737／28671），其中41—50岁的妇女HPV感染率高达19-42％（2470／12721），其次为5l。60岁年龄段的16．48％（1123／6816）。在≤40岁、城镇、大专及以上文化程度和人均年收入≥10000元的妇女人群中，HPV感染率分别为13-39％、12．53％、14．75％和14．37％，均低于其他组别，差异有统计学意义（X2=9．743、13．894、44．993和7．804，P均〈0．01）。4737例感染者中，共检出3614例HPV单一亚型感染，占HPV感染者的76．29％，其中3065例为单一高危亚型感染，占HPV单一亚型感染的84．81％。并以HPV16最为常见。占单一亚型35．00％（1265／3614）。结论高危型HPV感染在城镇、高收入、年龄≤40岁和高文化程度妇女中的发病率相对较低。HPV总感染率以41-50岁年龄段妇女最高，对30-60岁妇女进行常规筛查对降低宫颈癌发病率或有重要作用。Objective To investigate the prevalence of human papillomavirus （HPV） infection and Subtypes distribution among women of different ages in Shaanxi, and to provide basis for the prevention and treatment of cervical cancer. Methods PCR amplification in vitro combined reverse dot-blot hybridization assay were used to analyze HPV genotypes of 28 671 cervical exfoliated cell specimens. Results The percentage of I-IPV infection was 16.52% （4 737/28 671 ）. The percentage of HPV infection among women of 41-50 years old was 19.42% （2 470/ 12 721 ）, while the percentage among women of 51-60 was 16.48% （1 123/6 816）. HPV infection percentages in the group of 〈=40 years old （13.39%）, urban （12.53%）, junior college education or above （14.75%） and annual income〉=10 000 RMB （14.37%） were lower than their other groups （X2=9.743, 13.894, 44.993 and 7.804, P all〈 0.01 ）. The proportion of single genotype HPV infection was 76.29% （3 614/4 737 ）, among which 84.81% （3 065 / 3 614 ） were high-risk genotype HPV infections and HPV16 was the most popular genotype accounting for 35.00% （1 265 cases） of all single genotype infections. Conclusions In Shaanxi, women living in urban areas, with higher income, 〈---40 years old and high education level have a lower prevalence of high-risk HPV infections. The percentage of HPV infections is the highest among women of 41-50 years old. Routine screening of HPV infection among women of 30-60 years old may be useful for the cervical cancer prevention.

关 键 词：乳头状瘤病毒 人 亚型 多重感染 年龄分布 

分 类 号：R737.33[医药卫生—肿瘤]