肝损伤新标志物miR-122的研究进展  

Research progress on miR-122 as a novel biomarker of liver injury

作　　者：胥萍[1] 宋华峰[1] 张学光[2] 

机构地区：[1]江苏省苏州市第五人民医院检验中心苏州市感染免疫重点实验室,215007 [2]苏州大学生物技术研究所,江苏省苏州市215007

出　　处：《国际流行病学传染病学杂志》2015年第5期336-338,共3页International Journal of Epidemiology and Infectious Disease

基　　金：江苏省卫生厅资助项目（KF200974）;苏州市科技计划项目（SYS201433）

摘　　要：ALT和AST是临床上普遍用来诊断肝损伤程度的指标，但由于ALT和AST在血清中表达水平的升高还有可能来自其他临床疾病，从而降低了它们临床诊断肝损伤的价值。miR-122在肝组织中特异性高表达．且在外周血中具有良好的稳定性，因此miR-122被认为是一种全新的用来诊断肝损伤程度的特异性生物标志物。此文将miR-122作为新的肝损伤诊断指标的研究进展作一综述。ALT and AST are the most widely used biochemical markers of liver injury clinically. However, the elevated ALT and AST＂serum levels are known in some other diseases, which reduces the clinical diagnostic value. Therefore, miR-122, which is a highly specific expression in liver tissue and has good stability in peripheral blood, represents a novel and specific biochemical marker of liver injury. The research progress of miPt-122 as a novel biochemical marker for liver damage diagnosis is reviewed in this article.

关 键 词：丙氨酸转氨酶 天冬氨酸转氨酶 MIR-122 肝损伤 

分 类 号：R575[医药卫生—消化系统] R446.1[医药卫生—内科学]