首发未用药精神分裂症患者的认知功能与感觉门控P50的关系  

Correlation between cognitive function and P50 sensory gating in patients with drug-nave first-episode schizophrenia

作　　者：陈大春[1] 李艳丽[1] 杨可冰[1] 王宁[1] 聂鹰[1] 张进国[1] 张向阳[1] 

机构地区：[1]北京回龙观医院,北京100096

出　　处：《中国心理卫生杂志》2015年第10期733-737,共5页Chinese Mental Health Journal

基　　金：美国国立精神卫生研究所(NIMH)资助项目(H-22473);北京回龙观医院重点学科扶持基金(2014LYZD-02)

摘　　要：目的:探讨首发精神分裂症患者的认知功能与感觉门控P50关系。方法:使用美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)轴Ⅰ临床定式检查诊断首发精神分裂症住院患者106例,86名来自社区并且年龄、性别、受教育程度与患者匹配正常对照,采用听觉条件(S1)-测试(S2)刺激范式对所有研究对象进行P50检测,检测指标为S1、S2潜伏期和波幅,S2/S1抑制率,(Sl-S2)差值。根据抑制比,将S2/S1≤0.4定义为抑制比正常,S2/S1>0.4定义为抑制比异常。采用精神分裂症认知功能成套测验中文版(MCCB)评估所有对象认知功能。结果:精神分裂症患者的S1潜伏期、S2潜伏期长于正常对照组,S1波幅、(S1-S2)波幅低于对照组,S2/S1抑制率显著高于对照组(均P<0.01);精神分裂症患者的M CCB各维度得分均低于对照组(均P<0.05)。精神分裂症患者P50抑制率正常、异常者的M CCB分测验评分及总分差异无统计学意义(均P>0.05)。多元逐步回归分析显示P50抑制率、(S1-S2)波幅与M CCB评分的相关性无统计学意义(均P>0.05)。结论:首发精神分裂症患者的认知功能可能与感觉门控P50抑制缺陷无关联。Objective：To explore the relation of cognitive function correlates to P50 sensory gating in patients with schizophrenia.Methods：Totally 106 patients with drug-naiive first-episode schizophrenia and 86 healthy con-trol subjects matched for age,sex and education were recruited.All patients met the Diagnostic and Statistical Man-ual of Mental Disorders,Fourth Edition （DSM-IV）criteria for schizophrenia.Their cognitive function were assessed with the MATRICS Consensus Cognitive Battery （MCCB）.The P50 auditory gating potential were recorded in all subjects using conditioning-testing stimulus paradigm and stimulus train paradigm.The P50 components were meas-ured in S1 S2 latency,S1 S2 amplitude and P50 suppression ratios.Results：Compared with the controls subjects, the patients with schizophrenia had significantly longer S1[60.8 ±7.8）ms vs.（56.3 ±7.0）ms,P〈0.05]S2 la-tency [（59.1 ±10.2）ms vs.（55.7 ±10.7）ms,P 〈0.05],lower S1 amplitude [（2.8 ±1.8）μV vs.（3.5 ±1.6）μV,P 〈0.05],less amplitude difference （S1-S2）[（1.5 ±1.8）μV vs.（2.2 ±1.4）μV,P 〈0.05]and higher P50 suppression ratios （S2 /S1 ）[（59.7 ±65.6）vs.（37.6 ±30.0）,P 〈0.05].Schizophrenia patients had lower score than control subjects in all cognitive domains of MCCB （Ps 〈0.05）.No differences in neurocognitive performance were found between subjects in the normal P50 ratio and the abnormal in healthy controls or patients with schizo-phrenia （Ps 〉0.05）.No significant correlation was found between P50 gating measures （P50 ratio and P50 ampli-tude difference）and neuropsychological measures in MCCB scores （Ps ＆gt;0.05）.Conclusion：There may be no as-sociation between P50 deficits and cognitive measures in patients with drug-na＆#168;ive first-episode schizophrenia.

关 键 词：首发精神分裂症 听觉感觉门控 P50 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]