灼口综合征与焦虑抑郁症状的病例对照研究  

A case-control study of burning mouth syndrome and symptoms of anxiety and depression

作　　者：苏莎[1] 刘宏伟[1] 黄悦勤[2] 韩莹[1] 宋江园 木冬冬 季晓黎[1] 金建秋[1] 刘晓丹[1] 徐偲 

机构地区：[1]北京大学口腔医学院口腔黏膜科,北京100081 [2]北京大学第六医院,北京大学精神卫生研究所,卫生部精神卫生学重点实验室(北京大学),北京100091

出　　处：《中国心理卫生杂志》2015年第10期750-754,共5页Chinese Mental Health Journal

摘　　要：目的：分析灼口综合征（BMS）患者的焦虑及抑郁症状，探讨 BMS 的危险因素。方法：以口腔医院黏膜科诊断为 BMS 的147名患者作为病例组；以性别及年龄匹配的正常人群140人作为对照组，进行病例对照研究。采用自制的 BMS 危险因素问卷收集病例组和对照组的全身情况和药物史；采用焦虑自评量表和抑郁自评量表评价试验组和对照组的焦虑抑郁症状。统计方法包括 t 检验，χ2检验和 logistic 回归分析。结果：病例组焦虑症状评分高于对照组[（44.4±9.9）vs.（35.7±6.2）]，病例组抑郁症状评分高于对照组[（48.1±11.6）vs.（37.5±8.9）]，差异有统计学意义（P ＜0.001）。BMS 的危险因素为受教育程度低（OR ＝1.91，95％CI：1.04～3.49）、缺血性脑卒中史（OR ＝4.46，95％CI：1.87～10.95）、焦虑症状（OR ＝8.12，95％CI：2.60～25.37）及抑郁症状（OR ＝2.5795％CI：1.26～5.27）。结论：BMS是多因素导致的疾病，其中较低的受教育水平、缺血性脑卒中史、焦虑及抑郁症状是 BMS 的主要危险因素，对 BMS 的治疗应联合精神科，加强心理治疗手段。Objective：To evaluate the anxiety and depression symptoms of burning mouth syndrome （BMS）, and to explore risk factors to BMS.Method：In this case-control study,147 patients with BMS and 140 sex-and age-matched healthy volunteers were recruited.Three questionnaires were used to collect information of psychical and mental condition.The Self-Rating Anxiety Scale （SAS）and Self-Rating Depression Scale （SDS）were applied to evaluate symptoms of anxiety and depression.The scores of SAS and SDS were statistically analyzed by t-test.The risk factors of BMS were statistically analyzed by Chi-square test and logistic regression analysis.Result：The scores of SAS and SDS were higher in the patients with BMS than in the controls [SAS：（44.4 ±9.9）vs. （35.7 ±6.2）;SDS：（48.1 ±11.6）vs.（37.5 ±8.9）].The risk factors of BMS included ischemic stroke （OR =4.46,95%CI：1.87 -10.95）,low level of education （OR =1.91,95%CI：1.04 -3.49）,anxiety symptom （OR =8.12,95%CI：2.60 -25.37）and depression symptom （OR =2.57,95%CI：1.26 -5.27）.Conclusion：BMS is a multi-factorial disease.It indicates that ischemic stroke,lower level of education,anxiety symptom and depression symptom are the risk factors of BMS.A positive association could be established between psychological alterations and BMS.According to these findings it can be assumed that mental factors should be taking into account in the etiologyof BMS.It should be advocated to treat BMS patients by psychotherapy.

关 键 词：灼口综合征 焦虑 抑郁 疼痛 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R781.5[医药卫生—临床医学]