药用辅料接触角的测定及表面活性剂对辅料润湿性的调节作用  

Determination of contact angle of pharmaceutical excipients and regulating effect of surfactants on their wettability

作　　者：华东东 李鹤然 杨白雪[1] 宋立娜[1] 刘调调[1] 从禹堂 李三鸣[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《药学学报》2015年第10期1342-1345,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81473161)

摘　　要：采用量高法测定6种表面活性剂与常用辅料和辅料与表面活性剂混合物的接触角,以研究表面活性剂对辅料润湿性的影响。结果表明,水与辅料固体表面的接触角与辅料自身的亲水性有关,含亲水基团多的辅料片表面与水滴的接触角较小,接触角大小的顺序是:淀粉<苯甲酸钠<聚维酮<羧甲基纤维素钠<海藻酸钠<壳聚糖<羟丙甲基纤维素<硬脂酸镁;表面活性剂无论在溶液中还是混合于辅料固体中,均可明显降低辅料的接触角,不同表面活性剂降低接触角的能力不同。该研究结果对片剂处方设计具有参考价值。To study the effects of surfactants on wettability of excipients, the contact angles of six types of surfactants on the surface of two common excipients and mixture of three surfactants with excipients were measured using hypsometry method. The results demonstrated that contact angle of water on the surface of excipients was associated with hydrophilcity of excipients. Contact angle was lowered with increase in hydrophilic groups of excipient molecules. The sequence of contact angle from small to large was starch 〈 sodium benzoate 〈 polyvinylpyrrolidone 〈 sodium carboxymethylcellulose 〈 sodium alginate 〈 chitosan 〈 hydroxypropyl methyl cellulose 〈magnesium stearate. In addition, surfactants both in droplets and mixed in excipients significantly reduced the contact angle of excipients, and their abilities to lower contact angle varied. The results of the present study offer a guideline in the formulation design of tablets.

关 键 词：药用辅料 表面活性剂 接触角 润湿性 崩解 

分 类 号：R943[医药卫生—药剂学]