卵巢移行细胞癌的研究进展  

Research Progress in Ovarian Transitional Cell Carcinoma

作　　者：王琳琳 李新功 

机构地区：[1]山东省东营市人民医院病理科,山东东营257091

出　　处：《医学综述》2015年第19期3511-3513,共3页Medical Recapitulate

摘　　要：卵巢移行细胞癌少见,组织形态类似于泌尿系统的尿路上皮癌,曾被认为与卵巢Brenner肿瘤同属于卵巢移行细胞肿瘤。卵巢移行细胞癌从概念的提出就存在争议,其地位在WHO分类中也不断有变化,是一种值得关注的肿瘤。卵巢移行细胞癌没有Brenner肿瘤成分,可伴高级别浆液性癌,具有WT-1和p53异常表达,尿路上皮标志物阴性,组织形态和免疫组织化学与高级别浆液性癌更接近,不应与Brenner肿瘤归为同一类别,而应看作是高级别浆液性癌的形态变异。Ovarian transitional cell carcinoma （ TCC ） is rare, which is similar to the urinary system cancer in histomorphology and has been regarded with ovarian Brenner tumor as ovarian transitional cell tumors. The concept of TCC is controversial,and its status has been changing in the WHO category,which calls for due attention. Recent studies have shown that TCCs doesn′t have Brenner tumor content,but may contain high-grade serous carcinoma without,and has abnormal expression of WT-1 and p53 with negative of urinary tract epithelial markers,the histology and immunohistochemistry are closer to the high grade serous carcinoma. Therefore,TCC should not be categorized into the same category with Brenner tumor,but should be regarded as the morphological variation of high grade serous carcinomas.

关 键 词：卵巢肿瘤 移行细胞癌 病理学 

分 类 号：R737.31[医药卫生—肿瘤]