口腔黏膜下纤维性变并存口腔白斑和口腔扁平苔藓的回顾性研究  

A retrospective study of OSF coexisted with OLK or OLP

作　　者：彭解英[1] 吴颖芳[1] 魏高星[1] 李继佳[1] 马立为[1] 

机构地区：[1]中南大学湘雅医院口腔医学中心,长沙410008

出　　处：《中国医师杂志》2015年第9期1300-1304,共5页Journal of Chinese Physician

摘　　要：目的 观察口腔黏膜下纤维性变（OSF）并存口腔白斑（OLK）和OSF并存口腔扁平苔藓（OLP）的临床表现及病理特征,总结这两类疾病的共同特征及其各自的临床病理特点.方法 收集74例OSF并存OLK及57例OSF并存OLP患者的临床和病理资料并进行分析.结果 OSF并存OLK及OSF并存OLP均多见于青年男性、均有槟榔咀嚼史,大部分有吸烟饮酒史,张口受限均不明显;发生于单侧的OLK与OLP患者均有单侧咀嚼槟榔的习惯;并存OLP中糜烂型少于无槟榔咀嚼史的OLP患者;两者的病理均是在OSF的基础上发生并具有OLK或OLP的各自特点,上皮增厚多于上皮萎缩,OSF并存OLK上皮异常增生程度与纤维性变严重程度无明显相关性.结论 OSF并存OLK或OLP是在OSF病变基础上并发OLK或OLP,并非两种疾病的单纯叠加,而是具有OSF并发OLK/OLP各自的特征性表现.Objective To analyze the clinical feature and pathological characteristics of oral submucous fibrosis （OSF） coexisted with oral leukoplakia （OLK） or oral lichen planus （OLP）,and summarize both the common and each clinical and pathological characteristics of two kinds of diseases.Methods The clinical and pathological data of 74 patients with OSF coexisted with OLK and 57patients with OSF coexisted with OLP were retrospectively reviewed.Results Most of patients with OSF coexisted with OLK or OLP were mainly young and middle-aged male patients,and all had the habit of eating betel quid chewing.Most of them had the habit of smoking and alcohol drinking; while their limitation of mouth opening were not obvious.Patients coexisted with unilateral OLK or OLP all had a unilateral mastication of chewing betel nut;the prevalence rate of erosive OLP was lower in the patients with OSF coexisted OLP than that of OLP patients never chew betel nut.The pathology of both OSF coexisted with OLK or OLP was with the respective characteristics of OLK or OLP on the basis of OSF,and the epithelium was thickened more than atrophic.No relationship was found between the degree of epithelial hyperplasia and the severity of fibrosis in patients with OSF coexisted with OLK.Conclusions OSF coexisted with OLK and OSF coexisted with OLP were the occurrence of OLK or OLP on the basis of OSF,which were not a simple superposition of two diseases,but combination with their own characteristics of OSF coexisted with OLK or OLP.

关 键 词：口腔黏膜下纤维化/并发症 白斑 口控/并发症 扁平苔癣 口腔/并发症 

分 类 号：R781.5[医药卫生—口腔医学]