不同性别人群幽门螺杆菌感染与血脂异常的关系  

Association between helicobacter pylori infection and dyslipidemia in different gender population

作　　者：张艳[1] 李彩萍[1] 黄骁燕[1] 丁英俊[1] 张存秦[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院综合医疗科,武汉430030

出　　处：《中国医师杂志》2015年第9期1316-1319,1324,共5页Journal of Chinese Physician

基　　金：湖北省自然科学基金资助项目（2014CKB520）

摘　　要：目的 探讨幽门螺杆菌（HP）感染与不同性别人群血脂异常的关系.方法 对2010年1月至2012年6月1 921例体检者进行包括人口学特征、人体测量学、生活方式等横断面分析,并检测血脂水平和HP感染情况,比较不同性别人群HP感染与血脂异常的关系.结果 在女性人群中,HP感染阳性组总胆固醇/高密度脂蛋白胆固醇（TC/HDL）水平明显高于Hp感染阴性组（P＜0.05）,低密度脂蛋白胆固醇（LDL-c）水平差异无统计学意义（P＞0.05）.在男性人群中,HP感染阳性组LDL-c和TC/HDL-c水平均明显高于Hp感染阴性组（P＜0.05）.相关分析显示,无论男女HP感染阳性组发生高TC/HDL-c血症的风险均增加,女性HP感染阳性组为Hp感染阴性组的1.90倍（95％ CI,1.06～3.38）,男性HP感染阳性组为HP感染阴性组的1.56倍（95％ CI,1.21 ～2.00）.而仅在男性人群中,HP感染阳性组发生高LDL-c血症的风险增加,HP感染阳性组是HP感染阴性组2.33倍（95％ CI,1.34 ～4.06）.结论 HP感染可能引起机体血脂异常.Objective To assess the association between helicobacter pylori （HP） infection and dyslipidemia in different gender population.Methods We conducted cross-sectional analysis using data of 1921 cases of demographic characteristics,anthropometry,life style,lipid profile,etc.,from the subjects who received health examination from January 2010 to June 2012 in Department of Geriatrics,Tongji Hospital.Diagnosis of HP infection was achieved by using 14C-Urea Breath Test （14C-UBT）.The participants were divided into HP infection positive group and HP infection negative group by 14C-UBT.Results In female subjects,the levels of total cholesterol/high-density lipoprotein cholesterol （TC/HDL-c） were higher in HP positive group than HP negative group （P 〈 0.05）,but there was no obvious difference between the levels of low density lipoprotein cholesterol （LDL-c） in HP positive group and HP negative group.However,in the male subjects,the levels of LDL-c and TC/HDL-c were significantly increased in HP positive group than HP negative group （P 〈 0.05）.HP positive group had a greater risk for high TC/HDL-c both in female and male subjects.In female subjects,the risk for high TC/HDL-c in HP positive group was 1.90 times of that in HP negative group （95% CI,1.06 ～ 3.38）.In male subjects,the risk for high TC/HDLc in HP positive group was 1.56 times of that in HP negative group （95% CI,1.21 ～ 2.00）.But only in male subjects,the risk for high LDL-c in HP positive group was 2.33 times of that in HP negative group （95 % CI,1.34 ～ 4.06）.Conclusions We observed that HP infection was probability associated with dyslipidemia.

关 键 词：性别因素 螺杆菌感染/代谢 螺杆菌 幽门 血脂异常/病因学 

分 类 号：R573[医药卫生—消化系统]