新辅助化疗与术后辅助化疗在局部晚期乳腺癌治疗中的临床观察  

The Clinical Observation of Neoadjuvant Chemotherapy and Postoperative Adjuvant Chemotherapy in the Treatment of Locally Advanced Breast Cancer

作　　者：高勇[1] 张春梅 李治国[1] 张迪迪[1] 

机构地区：[1]河南省安阳市人民医院普外科,河南安阳455000 [2]锦州石化医院,辽宁锦州121001

出　　处：《辽宁医学院学报》2015年第5期47-48,66,共3页Journal of Liaoning Medical University (LNMU) Bimonthly

摘　　要：目的探讨新辅助化疗与术后辅助化疗在局部晚期乳腺癌治疗中的临床疗效。方法选择局部晚期乳腺癌患者56例,随机分为两组,新辅助化疗组采用CAF方案,术前进行2个周期化疗,术后进行4个周期化疗。对照组术后采用CAF方案进行6个周期化疗。比较两组手术切除率,3年生存率,5年局部复发率,5年远处转移率,5年生存率,5年无瘤生存率,以及治疗前后的CEA,CA-153水平。结果新辅助化疗组患者的手术切除率,3年生存率,5年生存率,5年无瘤生存率均明显高于对照组,5年局部复发率和5年远处转移率明显低于对照组,统计学均有显著性差异(P<0.05)。CEA和CA-153水平方面,新辅助化疗组两种肿瘤标志物水平术后下降明显多于对照组,具有显著性差异,P<0.05。结论新辅助化疗的临床疗效明显优于术后辅助化疗,值得推广。Objective To explore the clinical effects of neoadjuvant chemotherapy and postoperative adjuvant chemotherapy in the treatment of locally advanced breast cancer. Methods 56 patients with locally advanced breast cancer were randomly divided into two groups. The neoadjuvant chemotherapy group was treated with CAF, with 2 cycles of chemotherapy before the surgery and 4 cycles of chemotherapy after the surgery. The control group adopted CAF regimen for 6 cycles of chemotherapy. The surgical resection rate, 3 - year survival, 5 -year local recurrence, 5 -year distant metastasis rate, 5 -year survival rate, CEA, CA - 153 level before and after the treatment were compared between the two groups. Results The surgical resection rate, 3 - year survival rate, 5 - year survival rate, 5 - year disease - free survival rate of new adjuvant chemotherapy group were significantly higher than those of the control group. 5 - year local recurrence rate and 5 - year distant metastasis rate were significantly lower than those of the control group. They were sig- nificantly different （ P 〈 0.05 ）. The levels of CEA and CA - 153, two tumor markers in new adjuvant chemotherapy group were signifi- cantly higher than those in the control group. There were significant differences （ P 〈 0. 05 ）. Conclusion The clinical effect of neo- adjuvant chemotherapy is better than that of postoperative adjuvant chemotherapy and it is worth popularizing.

关 键 词：局部晚期乳腺癌 新辅助化疗 CAF方案 

分 类 号：R73-36[医药卫生—肿瘤]