合成二乙基甲氧基硼烷的工艺优化  

The Process Improvent on the Synthesis of Diethylmethoxyborane

作　　者：谢贤清[1] 范乃立[1] 邱曾烨 钟前[1] 廖维林[1] 

机构地区：[1]江西师范大学国家单糖化学合成工程技术研究中心,江西南昌330027

出　　处：《江西师范大学学报（自然科学版）》2015年第5期488-491,共4页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：国家科技支撑计划(2009BAI75B02);江西省青年成长基金(YC2014)资助项目

摘　　要：通过工业新工艺合成,以溴乙烷和镁粉为原料制备格氏试剂,与硼酸三甲酯发生亲核取代反应,经甲醇后处理得到二乙基甲氧基硼烷.考察了溶剂、原料配比、反应时间及温度等因素对二乙基甲氧基硼烷收率的影响,通过多次中试实验,获得了各步反应的最佳工艺参数,产品收率为84.4%,产物GC纯度为98.9%.Treated with methanol,diethylmethoxyborane is synthesized via the new industrial synthesis process by necleophilic substitution reaction between trimethylborate and griganrd reagent which prepared by bromoethane and magnesium as raw materials. The effects of solvent,the ratio of raw materials,reaction time and temperature on the yield were investigated. The optimum process parameters were obtained based on several pilot plant experiments,the yield of product was 84. 4% and the purity was 98. 9%.

关 键 词：硼酸三甲酯 溴乙烷 二乙基甲氧基硼烷 

分 类 号：TQ26[化学工程—有机化工]