局部亚低温对大鼠脑缺血组织钙调神经磷酸酶活性的影响  

EFFECT OF LOCAL MILD HYPOTHERMIA ON THE ACTIVITY OF CALCINEURIN IN ISCHEMIC CEREBRAL TISSUE IN RATS

作　　者：曹绪政[1] 兰杰[1] 徐建民[1] 邱朝晖[1] 

机构地区：[1]解放军第211医院

出　　处：《解放军医学杂志》2002年第8期719-720,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：为探讨局部亚低温的脑保护作用 ,制备大鼠大脑中动脉脑缺血模型。分为常温组、FK 5 0 6组、亚低温组和正常对照组 ,测定缺血后不同时间脑组织中钙调神经磷酸酶 (CaN)的活性。结果发现 ,常温组、FK 5 0 6组于缺血后 6hCaN活性开始下降 ,而亚低温组CaN活性无明显变化 ,差异有显著意义。说明局部亚低温治疗可明显抑制缺血脑组织中CaN活性的变化 ,具有明确的脑保护作用。To study the protective effect of local mild hypothermia on the ischemic cerebral tissue, a model of middle cerebral artery(MCA) occlusion was prepared in Wistar rats which were randomly divided into the normal temperature group, FK 506 group, mild hypothermia group and control group. The radioactivity of calcineurin in ischemic cerebral tissue was measured in different time after MCA occlusion. The activity of calcineurin decreased 6 hours after ischemia in the normal temperature group and the FK 506 group, whereas no obvious change of calcineurin activity was observed in the mild hypothermia group, which had a significant difference. It is suggested that the local mild hypothermia treatment may inhibit the change of calcineurin activity in ischemic cerebral tissue, and has a tangible protective effect on the ischemic brain.

关 键 词：钙调神经磷酸酶 亚低温 脑缺血 

分 类 号：R743.31[医药卫生—神经病学与精神病学]