The complex genetics in autism spectrum disorders  

作　　者：HUA Rui WEI MengPing ZHANG Chen 

机构地区：[1]State Key Laboratory of Membrane Biology, School of Life Sciences [2]PKU-IDG/Mc Govern Institute for Brain Research, Peking University

出　　处：《Science China(Life Sciences)》2015年第10期933-945,共13页中国科学（生命科学英文版）

基　　金：supported by National Basic Research Program of China(2011CB809102,2014CB942804,2014BAI03B01,2012YQ0302604);National Natural Science Foundation of China(31222025,31171025);Program for New Century Excellent Talents in University of Ministry of Education of China(ZC);the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry(ZC)

摘　　要：Autism spectrum disorders(ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants(CNVs), linkage regions, and micro RNAs have been associated with ASD which clearly indicates that ASD is a complex genetic disorder. Here, we will briefly summarize some of the high-confidence genetic changes in ASD and their possible roles in their pathogenesis.Autism spectrum disorders （ASD） are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants （CNVs）, linkage regions, and microRNAs have been associated with ASD which clearly indicates that ASD is a complex genetic disorder. Here, we will briefly summarize some of the high-confidence genetic changes in ASD and their possible roles in their pathogenesis.

关 键 词：autism spectrum disorders GENETICS causative genes copy number variants 

分 类 号：R749.94[医药卫生—神经病学与精神病学]