p-PI3K/p-AKT蛋白在神经母细胞瘤中的表达及意义  

Expression and clinical significance of p- PI3K/p- AKT protein in neuroblastoma

作　　者：王娟[1] 郭晓芳[1] 孙晓非[1] 甄子俊[1] 朱佳[1] 路素英[1] 孙斐斐[1] 陈燕[1] 张飞[1] 蔡瑞卿[1] 李梅[2] 

机构地区：[1]华南肿瘤学国家重点实验室中山大学肿瘤防治中心肿瘤医学协同创新中心儿童肿瘤科,广州510060 [2]华南肿瘤学国家重点实验室中山大学肿瘤防治中心肿瘤医学协同创新中心病理科,广州510060

出　　处：《广东医学》2015年第17期2629-2634,共6页Guangdong Medical Journal

摘　　要：目的探讨p-PI3K/p-AKT蛋白在神经母细胞瘤(NB)中的表达及其与临床特点和生存预后的关系。方法收集初治的、经病理证实的NB患者的临床资料和蜡块组织标本,采用免疫组化的方法检测NB组织中PI3K/AKT蛋白的表达,并分析其对患者生存预后的影响。结果 65例NB患者纳入研究,中位年龄3岁,中位随访时间38.6个月。p-PI3K和p-AKT在NB中的阳性表达率分别为70.7%(46/65)和70.7%(46/65)。pPI3K高表达41例(63.1%),p-AKT高表达43例(66.2%)。p-PI3K高表达与p-AKT高表达有关(P=0.021)。p-PI3K和p-AKT的表达与NB患者的临床特点及生存情况无明显相关性。结论 PI3K/AKT信号通路在NB患者中广泛表达,可能会为靶向治疗提供依据。Objective To investigate the expression of the p- PI3K/p- AKT protein and its correlations with clinical manifestations and prognosis in neuroblastoma（ NB）. Methods The clinical information and paraffin block of the tumor specimens of newly diagnosed,untreated patients with NB were collected. The expression of p- PI3 K / p- AKT in tumors was detected by immunohistochemistry,and its effect on survival of NB patients was analyzed. Results A total of 65 patients with NB were enrolled,with a median age of 3 years and a median follow- up time of 38. 6 months. The expression rates of p- PI3 K and p- AKT in NB patients were 70. 7%（ 46 /65） and 70. 7%（ 41 /65）,respectively. And the high expression rates were 63. 1%（ 41 /65） and 66. 2%（ 43 /65）,respectively. The expression level of the p- PI3 K in NB was positively correlated with that of p- AKT（ P = 0. 021）. But the expression level of p- PI3 K and p- AKT didn＇t affect the overall survival and didn＇t correlate with the clinical characteristics of the NB patients. Conclusion The PI3 K / AKT signal pathway was extensively expressed in patients with NB,which may reveal a promising therapeutic target for NB patients.

关 键 词：神经母细胞瘤 PI3K AKT 

分 类 号：R730.55[医药卫生—肿瘤]