肿瘤浸润淋巴细胞与胃癌预后关系的研究进展  

Research Progress of the Relationship Between Tumor Infiltrating Lymphocytes and Gastric Carcinoma

作　　者：黎鹏[1] 衣艳梅[1] 李淑贤[1] 

机构地区：[1]广东医学院组织胚胎学教研室,广东省东莞市523800

出　　处：《中国全科医学》2015年第28期3496-3500,共5页Chinese General Practice

基　　金：国家自然科学基金资助项目(81201763);湛江市科技攻关项目(2011C3108011)

摘　　要：胃癌是全球最常见的恶性肿瘤之一,影响胃癌预后的因素较多,患者的肿瘤局部免疫反应就是其中之一。近年来肿瘤浸润淋巴细胞成为胃癌预后的热点研究。本文介绍了胃癌肿瘤浸润淋巴细胞的亚型、临床分型及与患者预后关系的研究进展,认为胃癌内的调节性T细胞(Treg)通常与不利的预后相关,而肿瘤浸润的CD8+细胞毒性T细胞、CD45RO记忆T细胞、B淋巴细胞和淋巴小结通常与良好的胃癌预后相关,为进一步研究胃癌患者肿瘤局部免疫反应的关键机制和临床治疗提供了一定依据。Gastric cancer is one of the most common malignant tumors in the world. The influencing factors for gastric carcinoma are numerous,among which tumor local immune response is one of the influencing factors. In recent years,tumor infiltrating lymphocytes became a hot issue in the research of gastric cancer prognosis. In this paper,we introduced the subtypes and clinical classification of tumor infiltrating lymphocytes of gastric cancer. And we found that Treg in gastric carcinoma is normally associated with unfavorable prognosis,and tumor- infiltrating CD8＋CTLs,CD45 RO memory T cells,B lymphocyte and lymph nodules are normally associated with favorable prognosis of gastric carcinoma. The findings may provide a reference for the further research of the key mechanism of tumor local immune response in patients with gastric cancer and clinical treatment.

关 键 词：胃肿瘤 淋巴细胞 肿瘤浸润 预后 

分 类 号：R735.2[医药卫生—肿瘤]