Alginate-Casein Microspheres as Bioactive Vehicles for Nutrients  

作　　者：何志敏 张茜青 齐崴 黄仁亮 苏荣欣 

机构地区：[1]State Key Laboratory of Chemical Engineering,School of Chemical Engineering and Technology,Tianjin University [2]Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) [3]Tianjin Key Laboratory of Membrane Science and Desalination Technology,Tianjin University [4]School of Environmental Science and Engineering,Tianjin University

出　　处：《Transactions of Tianjin University》2015年第5期383-391,共9页天津大学学报（英文版）

基　　金：Supported by the National High Technology Research and Development Program of China("863"Program,No.2013AA102204);National Natural Science Foundation of China(No.31071509);program of Ministry of Science and Technology of China(No.2012YQ090194);Program of Beiyang Young Scholar of Tianjin University(2012);Program of Introducing Talents of Discipline to Universities of China(No.B06006)

摘　　要：The aim of this work was to develop an alginate-casein composite microsphere as a bioaetive vehicle for oral administration of nutrients by a simple extrusion dripping method. Riboflavin was selected as a model drug, and the microencapsulation efficiency was raised to 97.94% after optimizing the preparation conditions by response surface methodology. In vitro release studies showed that riboflavin was released completely from alginate-casein microspheres in simulated intestinal fluids. Meanwhile, the morphology, structure and interaction between alginate and casein were characterized by scanning electron microscopy （SEM） and Fourier transform infrared （FTIR） spectra.The aim of this work was to develop an alginate-casein composite microsphere as a bioactive vehicle for oral administration of nutrients by a simple extrusion dripping method. Riboflavin was selected as a model drug, and the microencapsulation efficiency was raised to 97.94% after optimizing the preparation conditions by response surface methodology. In vitro release studies showed that riboflavin was released completely from alginate-casein microspheres in simulated intestinal fluids. Meanwhile, the morphology, structure and interaction between alginate and casein were characterized by scanning electron microscopy(SEM) and Fourier transform infrared(FTIR) spectra.

关 键 词：ALGINATE CASEIN microcncapsulation response surface methodology bioactive peptides 

分 类 号：TQ464[化学工程—制药化工]