PGC-1α与肿瘤代谢关系的研究进展  

Advances in relationship between PGC-1α and tumor metabolism

作　　者：王旭[1] 沈颖[1] 沈培亮[1] 吴红雁[1] 祝娉婷[1] 陈文星[1,2,3] 王爱云[1,2,3] 陆茵[1,2,3] 

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]江苏省中药药效与安全性评价重点实验室,江苏南京210023 [3]江苏省中医药防治肿瘤协同创新中心,江苏南京210023

出　　处：《肿瘤》2015年第10期1158-1162,共5页Tumor

基　　金：国家自然科学基金资助项目(编号:81173174;81202655;81403260);2013年江苏高校优秀科技创新团队计划[编号:苏教科(2013)10号];江苏省中药学优势学科[编号:苏政办发(2014)37号];中国博士后科学基金(编号:2014M551639);江苏省博士后资助项目(编号:1401138C);江苏省自然科学基金(编号:BK2012854);江苏省2014年度普通高校研究生科研创新计划项目(编号:KYZZ_0270)~~

摘　　要：近年来,针对肿瘤代谢的研究已经成为肿瘤研究的新热点,而对代谢过程中关键调控因子的研究更是肿瘤代谢研究的重中之重,转录辅激活因子过氧化物酶体增殖物激活受体γ辅激活因子1α(peroxisome proliferators activated receptor gamma co-activator 1 alpha,PGC-1α)便是其中之一。PGC-1α是线粒体生物合成的关键调控因子,其在多种代谢性疾病中扮演着重要的角色,是氧化代谢和合成代谢的关键节点,参与了肿瘤代谢的调节,可以从氧化代谢和合成代谢两个方面调控肿瘤细胞的存活、增殖和迁移。本文对PGC-1α的结构及其相关转录因子进行了综述,探讨PGC-1α通过代谢调节肿瘤发生和发展的机制,并重点阐述了PGC-1α在肿瘤代谢研究中的进展,以期为后续以PGC-1α为靶标的抗肿瘤代谢的基础研究及药物研发提供新的理论参考。The research on tumor metabolism has become a new hotspot in recent years, of which the key regulatory molecules that mediating tumor metabolism are a priority for all. The transcriptional co- activator peroxisome proliferator-activated receptor gamma co- activator 1alpha （PGC-1α） is one of these key regulatory molecules. PGC-1α has been demonstrated to be a crucial regulatory molecule involved in a variety of metabolic diseases. It is also a key molecule in regulation of tumor metabolism, mediating oxidative metabolism and anabolism to participate in regulation of survival, proliferation and migration of tumor cells. This paper reviews the advances in research on structure of PGC-la and its related transcription molecules, and explores the mechanism of PGC-1α in regulation of occurrence and development of tumors, especiallyfocuses on advances in the role of PGC-1α in tumor metabolism, which may provide theoretical references for fundamental studies on antitumor metabolism based on PGC-1α target as well as the related drug development.

关 键 词：肿瘤 过氧化物酶体增殖物激活受体 代谢 转录激活因子类 

分 类 号：R730.2[医药卫生—肿瘤]