ER-α36与癌症的相关性  

Correlation of estrogen receptor-alpha 36 and cancer

作　　者：李佳男[1,2] 孙佳[1,2] 邹伟[1,2] 李洪艳[1,2] 

机构地区：[1]辽宁师范大学生命科学学院,辽宁大连116081 [2]辽宁省生物技术与分子药物研发重点实验室,辽宁大连116081

出　　处：《肿瘤》2015年第10期1170-1174,共5页Tumor

摘　　要：雌激素受体-α36(estrogen receptor-alpha 36,ER-α36)是近年来新发现的一种新型ER,其相对分子质量为3.57×104,在不同的组织器官中发挥着重要的生理功能。大量研究表明,肿瘤的发生、发展和ER-α36的表达水平有着密切关系,提示ER-α36可能作为一个潜在的靶点应用于某些肿瘤的治疗。本文对ER-α36与乳腺癌、胃癌和肝癌等肿瘤的相关性研究进展进行综述。Estrogen receptor-alpha 36 （ER-α36）, which is a new type of ER with a relative molecular weight of 3.57）〈104, has been demonstrated to have many important physiological functions in different tissues and organs in recent years. Many studies have shown that the occurrence and development of cancer are closely related to the expression level of ER-α36, which suggests that ER-α36 may serve as a potential therapeutic target in the treatment of some cancers. This paper reviews the advances in research on the correlation between ER-α36 and some cancers such as breast cancer, gastric cancer, liver cancer, and so on.

关 键 词：雌激素受体Α 肿瘤形成过程 基因表达 基因疗法 雌激素 受体ER-α36 

分 类 号：R730.231[医药卫生—肿瘤]