N-甲基-D-天冬氨酸受体NR2B亚单位在神经病理性疼痛中的作用及其研究进展  

The research and development of N-methyl-D-aspartate receptor containing NR2B subunit and its role in the neuropathic pain

作　　者：黄娅琴[1] 雷卫平[1] 孙建良[2] 

机构地区：[1]温州医科大学第二临床医学院麻醉科,325027 [2]杭州市第一人民医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2015年第10期933-936,共4页International Journal of Anesthesiology and Resuscitation

基　　金：杭州市卫生科技计划重点项目（2014205）

摘　　要：背景N-甲基-D-天冬氨酸（N-methyl-D-aspartate，NMDA）受体是一种门控离子型谷氨酸受体，包括NR1、NR2A-D、NR3A～B等7个亚型。研究发现NMDA受体NR2B亚单位在中枢性痛觉敏化形成和神经病理性疼痛（neuropathicpain，NP）的发病机制及其治疗中有重要作用。目的结合文献就NR2B亚单位在NP中的作用及其研究进展进行综述。内容分别介绍NMDA受体NR2B亚单位的结构与功能、中枢分布及其在NP中的作用，NR2B选择性拮抗剂的镇痛效应等相关内容。趋向NMDA受体NR2B亚单位与NP的关系密切，NR2B亚单位有望成为治疗NP的重要靶点。Backgroud N-methyl-D-aspartate （NMDA） receptor is a kind of gating ionic glutamate receptors composed of seven subunits,including NR1, NR2A-D and NR3A-B . It has been found that NR2B subunit of NMDA receptor plays an important role in the formation of central pain sensitization and in the pathogenesis and treatment of neuropathie pain （NP）. Objective Combined with literature,we summarize the research, development and the role of NR2B subunit in the NP. Content This paper describes the structure and function of NMDA receptor NR2B subunit, its central distribution and the role in the NP, the analgesic action of NR2B selectivity antagonists. Trend NMDA receptor NR2B subunit has close relationship with NP and NR2B subunit is expected to become important targets for the treatment of NP.

关 键 词：N-甲基-D-天冬氨酸受体 NR2B亚单位 神经病理性疼痛 长时程增强 突触可塑性 

分 类 号：R741[医药卫生—神经病学与精神病学]