与结直肠癌转移相关的微小RNA研究现状  

Review of microRNA related to the metastasis of colorectal cancer

作　　者：彭永红[1] 蔡国豪[1] 喻学桥[1] 周卫平[1] 

机构地区：[1]海南省人民医院消化外科,海口570311

出　　处：《中国临床药理学杂志》2015年第20期2080-2083,共4页The Chinese Journal of Clinical Pharmacology

基　　金：海南省自然科学基金资助项目(813203)

摘　　要：瘤转移是结直肠癌患者死亡的主要原因之一。microRNA(miRNA)对结直肠癌转移的作用包括调节肿瘤细胞上皮-间质转化、调控癌基因、抑癌基因以及肿瘤转移相关基因的表达等,通过与靶基因mRNA互补位点结合,在转录后水平调控靶基因的表达,进而调控肿瘤的发生、发展。近年来,越来越多的研究显示,miRNA在结直肠癌的侵袭转移中起重要的作用,有望成为结直肠癌治疗的新靶点。Metastasis is one of the leading cause of death in patients with colorectal cancer. MicroRNA （miRNA） can regulate epithelial- mesen- chymal transition, oncogenes, tumor suppressor genes and tumor metasta- sis related genes, and combine target gene mRNA by binding to comple- mentary sites to regulate the expression of target genes in post - transcrip- tional, thus regulate the tumor occurrence and development. In recent years, more and more studies show that miRNAs play important roles in the metastasis of colorectal cancer, which is expected to become a new target for the treatment of colorectal cancer.

关 键 词：结直肠癌 转移 微小RNA 相关性 

分 类 号：R735.37[医药卫生—肿瘤] R968[医药卫生—临床医学]