胃癌Lauren分型临床特点及预后分析  

Clinicopathological characteristics and prognosis of gastric adenocarcinoma with different Lauren classification

作　　者：白鸽[1] 初建虎[2] 郑超[1] 马乐[1] 包永星[1] 玛依努尔.艾力 

机构地区：[1]新疆医科大学第一附属医院肿瘤中心,乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院胸外科,乌鲁木齐830011

出　　处：《新医学》2015年第10期682-684,共3页Journal of New Medicine

摘　　要：目的比较弥漫型胃癌与肠型胃癌临床病理特点及预后。方法回顾性分析603例胃癌患者,其中肠型胃癌297例、弥漫型306例,分析两者在民族、肿瘤大小、淋巴结转移情况、浸润深度、淋巴结及远处转移状况、分化程度和肿瘤TNM分期、Her-2基因状态上的差异。结果与肠型胃癌相比,弥漫型胃癌患者较年轻、女性多见、肿瘤分期多为中晚期、组织分化程度较差、更易出现淋巴结转移及腹膜转移、Her-2基因阳性率偏低、WHO病理分型以低分化、印戒细胞癌为主(P<0.05)。弥漫型与肠型胃癌患者的5年总生存率分别为41.8%和52.8%(P<0.001)。结论弥漫型胃癌组织分化差,肿瘤恶性程度高,预后较差,而肠型胃癌的预后较好。Objective To compare the clinicopathological features and prognosis between diffuseand intestinal-type gastric cancer. Methods A retrospective analysis of 603 cases of gastric cancer,including 297 cases of intestinal-type and 306 diffuse-type gastric cancer,was conducted to compare the differences in terms of ethnics,tumor size,lymph node metastasis,depth of invasion,lymph node and distant metastasis,differentiation status and TNM staging and Her-2 gene status. Results Compared with intestinal-type gastric cancer,diffuse gastric cancer mainly occurred at a younger age of onset,female preponderance,most in moderate and advanced stage of tumor,lower degree of histological differentiation,more likely to have lymph node metastasis and peritoneal metastasis,lower positive rate of Her-2 gene and poorly differentiated signet ring cell carcinoma by WHO pathological classification（ P〈0. 05）. The 5-year overall survival of diffuse-type and intestinal-type gastric cancer was 41. 8% and 52. 8%（ P〈0. 001）. Conclusions Diffuse gastric cancer presents with low histological differentiation,high degree of malignancy and poor prognosis,whereas the clinical prognosis of intestinal-type gastric cancer is better.

关 键 词：胃癌 Lauren分型 预后 

分 类 号：R735.2[医药卫生—肿瘤]