Induced neural stem/precursor cells for fundamental studies and potential application in neurodegenerative diseases  

作　　者：Ting Shen Jiali Pu Tingting Zheng Baorong Zhang 

机构地区：[1]Department of Neurology, Second Affi liated Hospital, School of Medicine, Zhejiang University

出　　处：《Neuroscience Bulletin》2015年第5期589-600,共12页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (81271248 and 81400933)

摘　　要：Recent research has shown that defined sets of exogenous factors are sufficient to convert rodent and human somatic cells directly into induced neural stem cells or neural precursor cells（iNSCs/iNPCs）.The process of transdifferentiation bypasses the step of a pluripotent state and reduces the risk of tumorigenesis and genetic instability while retaining the self-renewing capacity.This iNSC/iNPC technology has fueled much excitement in regenerative medicine,as these cells can be differentiated into target cells for replacement therapy for neurodegenerative diseases.Patients＇ somatic cell-derived iNSCs/iNPCs have also been proposed to serve as disease models with potential value in both fundamental studies and clinical applications.This review focuses on the mechanisms,techniques,and applications of iNSCs/iNPCs from a series of related studies,as well as further efforts in designing novel strategies using iNSC/iNPC technology and its potential applications in neurodegenerative diseases.Recent research has shown that defined sets of exogenous factors are sufficient to convert rodent and human somatic cells directly into induced neural stem cells or neural precursor cells（iNSCs/iNPCs）.The process of transdifferentiation bypasses the step of a pluripotent state and reduces the risk of tumorigenesis and genetic instability while retaining the self-renewing capacity.This iNSC/iNPC technology has fueled much excitement in regenerative medicine,as these cells can be differentiated into target cells for replacement therapy for neurodegenerative diseases.Patients＇ somatic cell-derived iNSCs/iNPCs have also been proposed to serve as disease models with potential value in both fundamental studies and clinical applications.This review focuses on the mechanisms,techniques,and applications of iNSCs/iNPCs from a series of related studies,as well as further efforts in designing novel strategies using iNSC/iNPC technology and its potential applications in neurodegenerative diseases.

关 键 词：induced neural stem cell induced neural precursor cell transdifferentiation fundamental study clinical application neurodegenerative disease 

分 类 号：R741[医药卫生—神经病学与精神病学]