血清S100A6检测对卵巢上皮性癌的诊断价值  

Study on Diagnostic Value of Detecting Serum S100A6 in the Epithelial Ovarian Carcinoma

作　　者：郑福利[1] 张颖[2] 王建[3] 

机构地区：[1]陕西中医学院第二附属医院妇产科,陕西咸阳712000 [2]解放军第三二三医院妇产科,西安710054 [3]第四军医大学西京医院妇产科,西安710032

出　　处：《现代检验医学杂志》2015年第5期22-23,27,共3页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金资助项目（NO：81172458）;国家自然科学基金资助项目（NO：81302243）.

摘　　要：目的 探讨血清S100A6对卵巢上皮性癌的诊断及疾病进展临床诊断的指导价值.方法 采用酶联免疫吸附测定法（ELISA）检测40例卵巢上皮性癌患者、20例卵巢良性肿瘤患者及20例正常体检者血清中S100A6的浓度.结果 卵巢癌与良性卵巢肿瘤,正常对照患者相比,S100A6血清浓度显著升高,差异具有统计学意义（t=2.66,P＜0.01）.中晚期（Ⅲ＋Ⅳ期）卵巢癌患者S100A6血清浓度显著高于早期（Ⅰ＋Ⅱ期）卵巢癌患者（t=4.68,P＜0.001）.与高分化和中分化相比,低分化的卵巢癌患者S100A6血清浓度显著升高,差异有统计学意义（t=2.49,P＜0.05）.出现淋巴结转移的卵巢癌患者中S100A6血清浓度显著高于淋巴结无转移的卵巢癌患者（t=4.02,P＜0.01）.S100A6血清平均浓度与病理类型无关（t=1.8,P＞0.05）.结论 血清S100A6的血清浓度与卵巢癌病情发展相关,S100A6有望成为监测卵巢上皮性癌病情发展的分子标志物.Objective To investigate the significance of serum S100A6 in epithelial ovarian carcinoma and explore the correla tion between the serum S100A6 and clinicopathologic features. Methods The serum S100A6 level in 40 patients with epithe- lial ovarian carcinoma and 20 benign ovarian tumor group ,20 normal control group were measured by enzyme-linked immu- nosorbent assay （ELISA）. Results The serum S100A6 level was significantly higher in the EOC group than in the benign o- varian tumor group and normal control group （t= 2.66,P〈0.01）. The serum S100A6 level was obviously increased in ad- vanced stage EOC patients compared with early stage EOC patients （t= 4.68, P〈0. 001）. The serum S100A6 level was sig- nificantly higher in the poor-differentiated group than in the well-differentiated group and moderate-differentiated group （t= 2.49,P〈0.05）. The serum S100A6 level in lymph node metastasis was obviously higher than nolymph node metastasis in EOC patients （t=4.02,P〈0.01）. The serum S100A6 level was no difference between seroustype and other spathological type （t= 1.8,P〈0.05）. Conclusion The data suggested that serum S100A6 level can indicate the progression of epithelial ovarian carcinoma,and may be a new promising approach in targeting therapy of ovarian cancer.

关 键 词：卵巢癌 钙结合蛋白S100A6 临床诊断 

分 类 号：R737.31[医药卫生—肿瘤] R730.43[医药卫生—临床医学]