血清AFP,CEA,CA-199与TAP在肝癌诊断中的应用价值  

Application Value of Serum AFP, CEA, CA-19 9 and TAP in the Diagnosis of Hepatocellular Carcinoma

作　　者：王芳胜[1] 熊敦勇[1] 寇辉[1] 任光玉[1] 张剑锋[1] 朱皓皞[1] 

机构地区：[1]中国人民解放军第九四医院,江西南昌330002

出　　处：《现代检验医学杂志》2015年第5期148-150,共3页Journal of Modern Laboratory Medicine

摘　　要：目的 探讨血清甲胎蛋白（AFP）,癌胚抗原（CEA）,糖链抗原199（CA-199）与糖链糖蛋白（TAP）在肝癌诊断中的应用价值.方法 收集69例肝癌患者为研究对象,比较各肿瘤标记物（TM）的敏感度、特异度及阳性率等指标.结果 肝癌确诊患者中,TAP,CEA,AFP,CA-199及联合检测敏感度分别为88.40％,40.60％,53.6％,34.80％和95.60％;阳性率分别为68.40％,40.54％,46.84％,34.23％和75.67％.四项肿瘤标记物联合检测敏感度（95.60％）和阳性率（75.67％）明显高于其他各单项检测指标,特别是在继发性肝癌中,联合检测起到明显弥补作用.结论 四项肿瘤标记物联合检测优于AFP,CEA,CA-199和TAP各单项检测,是一个很好的肝癌筛查方法.Objective To explore the application value of serum CEA,AFP,CA-199 and TAP in the diagnosis of liver cancer. Methods It collected 69 hospitalized patients of liver cancer. And researched the TM detection sensitivity,specificity,posi- tive rate and other indicators. Results From diagnosed HCC patients found that TAP,CEA,AFP,CA-199 and combined de- tection sensitivity were 88.40%, 40.60%, 53.6%, 34.80% and 95. 60% respectively. The positive rate of those were 68.40%,40.54%, 46.84%, 34.23% and 75.67% respectively. It was obviously that four TM were more sensitive （95.60%） and positive rate （75.67%） for individual detection than other indicators. Conclusion The joint detection of four TM were more sensitive to detect the individual than AFP,CEA,CA-199 and TAP. So can consider it as a better liver cancer screening method.

关 键 词：异常糖链糖蛋白 甲胎蛋白 癌胚抗原 糖链抗原199 肝癌 

分 类 号：R735.7[医药卫生—肿瘤] R730.43[医药卫生—临床医学]